-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】6-Fluoro-3-(4-methylpiperazin-1-ylcarbonyl)quinoline-4(1H)-one

【CA登记号】

【分子式】C₁₅H₁₆FN₃O₂

【分子量】289.31207

【开发单位】Central Drug Research Institute (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases

合成路线1

Title compound was synthesized by condensation of ethyl 6-fluoro-4-quinolone-3-carboxylate (I) with N-methylpiperazine (II) in pyridine at 120 C under pressure.

参考文献中间体

【1】 Srivastava S; Srivastava, S.K.; Shukla, A.; Chauhan, P.M.; Puri, S.K.; Bhaduri, A.P.; Pandey, V.C.; Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone. Bioorg Med Chem Lett 1999, 9, 1, 25.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19903	ethyl 6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate		C₁₂H₁₀FNO₃	详情	详情
(II)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情

Extended Information