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【结 构 式】 
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【分子编号】19440 【品名】(4-[2-[(E)-4-(dimethylamino)butylidene]hydrazino]phenyl)-N-methylmethanesulfonamide 【CA登记号】 |
【 分 子 式 】C14H24N4O2S 【 分 子 量 】312.43632 【元素组成】C 53.82% H 7.74% N 17.93% O 10.24% S 10.26% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)2) The condensation of hydrazine (II) with 4,4-dimethoxy-N,N-dimethylbutylamine (VIII) by means of HCl in water gives the butylidenehydrazino compound (IX), which is cyclized with polyphosphate ester (PPE) in CHCl3.
| 【1】 Coates, I.H.; Dowle, M.D. (Glaxo Group Ltd.); Heterocyclic compounds.. FR 2530625; GB 2124210; US 4816470 . |
| 【2】 Oxford, A.W. (Glaxo Group Ltd.); An indole derivative.. GB 2162522 . |
| 【3】 Humphrey, P.P.A.; Feniuk, W.; Perren, M.J.; Oxford, A.W.; Brittain, R.T.; Prous, J.; Castaner, J.; SUMATRIPTAN SUCCINATE < Prop INNM; BAN >. Drugs Fut 1989, 14, 1, 35. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19432 | (4-aminophenyl)-N-methylmethanesulfonamide; 4-amino-N-ethylbenzylmethanesulfamide | 109903-35-7 | C8H12N2O2S | 详情 | 详情 |
| (II) | 19433 | (4-hydrazinophenyl)-N-methylmethanesulfonamide | 88933-16-8 | C8H13N3O2S | 详情 | 详情 |
| (III) | 19439 | 4,5-diethoxy-N,N-dimethyl-1-pentanamine; N-(4,5-diethoxypentyl)-N,N-dimethylamine | C11H25NO2 | 详情 | 详情 | |
| (IX) | 19440 | (4-[2-[(E)-4-(dimethylamino)butylidene]hydrazino]phenyl)-N-methylmethanesulfonamide | C14H24N4O2S | 详情 | 详情 |
Extended Information