4,5-diethoxy-N,N-dimethyl-1-pentanamine; N-(4,5-diethoxypentyl)-N,N-dimethylamine -Drug Synthesis Database

【结构式】

【分子编号】19439

【品名】4,5-diethoxy-N,N-dimethyl-1-pentanamine; N-(4,5-diethoxypentyl)-N,N-dimethylamine

【CA登记号】

【分子式】C₁₁H₂₅NO₂

【分子量】203.32504

【元素组成】C 64.98% H 12.39% N 6.89% O 15.74%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

2) The condensation of hydrazine (II) with 4,4-dimethoxy-N,N-dimethylbutylamine (VIII) by means of HCl in water gives the butylidenehydrazino compound (IX), which is cyclized with polyphosphate ester (PPE) in CHCl3.

参考文献中间体

合成目标

【1】 Coates, I.H.; Dowle, M.D. (Glaxo Group Ltd.); Heterocyclic compounds.. FR 2530625; GB 2124210; US 4816470 .
【2】 Oxford, A.W. (Glaxo Group Ltd.); An indole derivative.. GB 2162522 .
【3】 Humphrey, P.P.A.; Feniuk, W.; Perren, M.J.; Oxford, A.W.; Brittain, R.T.; Prous, J.; Castaner, J.; SUMATRIPTAN SUCCINATE < Prop INNM; BAN >. Drugs Fut 1989, 14, 1, 35.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19432	(4-aminophenyl)-N-methylmethanesulfonamide; 4-amino-N-ethylbenzylmethanesulfamide	109903-35-7	C₈H₁₂N₂O₂S	详情	详情
(II)	19433	(4-hydrazinophenyl)-N-methylmethanesulfonamide	88933-16-8	C₈H₁₃N₃O₂S	详情	详情
(III)	19439	4,5-diethoxy-N,N-dimethyl-1-pentanamine; N-(4,5-diethoxypentyl)-N,N-dimethylamine		C₁₁H₂₅NO₂	详情	详情
(IX)	19440	(4-[2-[(E)-4-(dimethylamino)butylidene]hydrazino]phenyl)-N-methylmethanesulfonamide		C₁₄H₂₄N₄O₂S	详情	详情

Extended Information