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【结 构 式】 
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【分子编号】19266 【品名】4-bromophenyl methyl sulfide; 1-bromo-4-(methylsulfanyl)benzene 【CA登记号】104-95-0 |
【 分 子 式 】C7H7BrS 【 分 子 量 】203.10258 【元素组成】C 41.4% H 3.47% Br 39.34% S 15.79% |
合成路线1
该中间体在本合成路线中的序号：(I)Methiothepin can be prepared in several ways, two of which have been described with experimental details. The common intermediate of both is the ketone (VIII). 4-Bromothioanisol (I) is converted to the Grignard reagent, which is treated with sulfur yielding 4-(methylthio)thiophenol (II). The same compound is accessible by reduction of 4-(methylthio)benzenesulfonyl chloride (A), done best with phosphorus and iodine in acetic acid. The potassium salt of (II) is treated with a boiling solution of potassium 2-iodobenzoate (B) in the presence of copper giving 2-(4-methylthiophenylthio)benzoic acid (III). Further reduction with LiAlH4 results in 2-(4-methylthiophenylthio)benzyl alcohol (IV). This reduction proceeds very well with NaAlH2(OCH2CH2OCH3)2 in benzene. (IV) is then converted with SOCl2 in benzene to the chloride (V), which is treated with NaCN or KCN in boiling aqueous ethanol to give the nitrile (VI). Hydroysis with KOH in aqueous ethanol yields 2-(4-methylthiophenylthio)phenylacetic acid (VII), which is cyclized with polyphosphoric acid to 8-(methylthio)dibenzo[b,f]thiepin-10(11H)-one (VIII). The ketone (VIII) may be reduced with NaBH4 to the alcohol (IX), which is transformed by treatment with anhydrous HCl in benzene to the chloride (X). Substitution reaction with 1-methylpiperazine (C) at 120-130 C or more in boiling chloroform gives 80% crude metitepine base, which is transformed to the maleate. The other method consists first in transforming the ketone (VIII) into the methylpiperazine enamine (XI) by treatment with 1-methylpiperazine (C) and TiCl4 in boiling benzene. The enamine (XI) is then reduced to metitepine; the best method of reduction for this particular case seems to be the treatment with diborane generated by interaction of NaBH4 with acetic acid in tetrahydrofuran. An additional three methods of metitepine synthesis are covered by patents; howewer, they do not describe experimental details for the particular case of metitepine.
| 【1】 Jilek, J.O.; et al.; Neurotropic and psychotropic substances. XLIV. 10-Aminoalkoxy and 10-piperazino derivatives of dibenzo[b,f]thiepin and related systems. Czech Chem Commun 1970, 35, 3721-32. |
| 【2】 Kyburz, E.; Methiothepin, octoclothepin and related neuroleptic agents. Commun at the Rest Inst Pharm Biochem in Prague, June 5, 1974 1974, 25, 1, 20. |
| 【3】 Pelz, K.; et al.; Neurotrope und psychotrope Substanzen. XXV. Uber die in 8.Stellung durch die Methyl-, -tert-Butyl-, Methoxy-, Methylthio- und Methansulfonylgruppe substituierten 10-(4-Methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin-Derivate. Coll Czech Chem Commun 1968, 33, 1895-1910. |
| 【4】 Kaplan, J.P.; Kyburz, E.; Process for benzothiepins. CH 555856; CH 563389; DE 2216883; FR 2135174; GB 1361717; US 3811026 . |
| 【5】 Protiva, M.; et al.; Piperazinyldibenzothiepines. DE 1620382; FR 1484332; GB 1123400; US 3379729 . |
| 【6】 Jilek, J.O.; et al.; 8-Chlor-10-(4-methylpiperazino)dibenzo[b,f]thiepin und Analoga; neue hoch wirksame Neuroleptica. Naturwissencshaften 1969, 56, 374. |
| 【7】 Protiva, M.; et al.; Procede de preparation de la methyl-piperazine et de leurs sels, ainsi que les produits obtenus. FR 2151568; ZA 7104647 . |
| 【8】 Protiva, M.; et al.; Procede de preparation d'amines heterocycliques et de leurs sels et produits obtenus par ce procede. ES 394172; FR 2099683 . |
| 【9】 Protiva, M.; et al.; Verfahren zur Herstellung von neuroleptisch wirksamen 10-Piperazino-10,11-dihydrodibenzo[b,f]thiepinen. AT 310170B; CH 544771; ES 385836; NL 7017200; ZA 7007985 . |
| 【10】 Protiva, M.; et al.; Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo[b,f]thiepins and a method of preparing same. DE 2026027; ES 380127; FR 2043741; GB 1313428 . |
| 【11】 Kyburz, E.; Uber Methiothepin und verwandte Dibenzo[b,f]thiepin und -oxepin-Derivate. Schweiz Chem Ges, Herbstversammlung, Neuchatel, Oct. 12, 1974 1974, 106, 19, Suppl. 2. |
| 【12】 Jilek, J.O.; et al.; 8-Alkylthio-10-piperazinodibenzo[b,f]thiepins. Coll Czech Chem Commun 1974, 39, 3338-51. |
| 【13】 Protiva, M.; Metitepine. Drugs Fut 1977, 2, 4, 250. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 40103 | 4-methanesulfonylbenzene-1-thiol | C7H8O2S2 | 详情 | 详情 | |
| (B) | 40105 | potassium 2-iodobenzoate | C7H4IKO2 | 详情 | 详情 | |
| (I) | 19266 | 4-bromophenyl methyl sulfide; 1-bromo-4-(methylsulfanyl)benzene | 104-95-0 | C7H7BrS | 详情 | 详情 |
| (II) | 40104 | 4-(methylsulfanyl)benzenethiol; 4-(methylsulfanyl)phenylhydrosulfide | 1122-97-0 | C7H8S2 | 详情 | 详情 |
| (III) | 40106 | 2-[[4-(methylsulfanyl)phenyl]sulfanyl]benzoic acid | C14H12O2S2 | 详情 | 详情 | |
| (IV) | 40107 | (2-[[4-(methylsulfanyl)phenyl]sulfanyl]phenyl)methanol | C14H14OS2 | 详情 | 详情 | |
| (V) | 40108 | 1-(chloromethyl)-2-[[4-(methylsulfanyl)phenyl]sulfanyl]benzene; 2-(chloromethyl)phenyl 4-(methylsulfanyl)phenyl sulfide | C14H13ClS2 | 详情 | 详情 | |
| (VI) | 40109 | 2-(2-[[4-(methylsulfanyl)phenyl]sulfanyl]phenyl)acetonitrile | C15H13NS2 | 详情 | 详情 | |
| (VII) | 40114 | 2-(2-[[4-(methylsulfanyl)phenyl]sulfanyl]phenyl)acetic acid | C15H14O2S2 | 详情 | 详情 | |
| (VIII) | 40110 | 8-(methylsulfanyl)dibenzo[b,f]thiepin-10(11H)-one | C15H12OS2 | 详情 | 详情 | |
| (IX) | 40111 | 8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-ol | C15H14OS2 | 详情 | 详情 | |
| (X) | 40112 | 11-chloro-2-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepine; 11-chloro-10,11-dihydrodibenzo[b,f]thiepin-2-yl methyl sulfide | C15H13ClS2 | 详情 | 详情 | |
| (XI) | 40113 | methyl 11-(4-methyl-1-piperazinyl)dibenzo[b,f]thiepin-2-yl sulfide; 1-methyl-4-[8-(methylsulfanyl)dibenzo[b,f]thiepin-10-yl]piperazine | C20H22N2S2 | 详情 | 详情 | |
| (C) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XIV)6) The reaction of 4-bromothioanisole (XIV) with furan-2(5H)-one (XV) by means of tert-BuLi/CuI in ethyl ether, followed by silylation with trimethylsilyl chloride gives 4-[4-(methylsulfanyl)phenyl]-2-(trimethylsilyloxy)-3,4-dihydrofuran (XVI), which is desilylated with palladium acetate in acetonitrile to afford the furanone (XVII). The iodination of (XVII) with I2 in pyridine yields 3-iodo-4-[4-(methylsulfanyl)phenyl]furan-2(5H)-one (XVIII), which is condensed with phenylboronic acid (XIX) by means of triphenylarsine and a Pd catalyst in refluxing benzene, giving 4-[4-(methylsulfanyl)phenyl]-3-phenylfuran-2(5H)-one (VIII), already described in Scheme 1. Finally, this compound is oxidized with monoperoxyphthalic acid magnesium salt in dichloromethane/methanol.
| 【1】 Sorbera, L.A.; Rabasseda, X.; Castañer, J.; Rofecoxib. Drugs Fut 1998, 23, 12, 1287. |
| 【2】 Atkinson, J.G.; Wang, Z. (Merck Frosst Canada Inc.); Stilbene derivs. useful as cyclooxygenase-2 inhibitors. EP 0788476; JP 1998507765; WO 9613483 . |
| 【3】 Hancock, B.; Winters, C.; Gertz, B.; Ehrich, E. (Merck & Co., Inc.; Merck Frosst Canada Inc.); Compsns. for a once a day treatment of cyclooxygenase-2 mediated diseases. JP 1999512754; WO 9744028 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIII) | 19260 | 4-[4-(methylsulfanyl)phenyl]-3-phenyl-2(5H)-furanone | C17H14O2S | 详情 | 详情 | |
| (XIV) | 19266 | 4-bromophenyl methyl sulfide; 1-bromo-4-(methylsulfanyl)benzene | 104-95-0 | C7H7BrS | 详情 | 详情 |
| (XV) | 19267 | 2(5H)-furanone；furan-2(5H)-one；2-Buten-1,4-olide | 497-23-4 | C4H4O2 | 详情 | 详情 |
| (XVI) | 19268 | trimethyl([4-[4-(methylsulfanyl)phenyl]-4,5-dihydro-2-furanyl]oxy)silane; 4-[4-(methylsulfanyl)phenyl]-4,5-dihydro-2-furanyl trimethylsilyl ether | C14H20O2SSi | 详情 | 详情 | |
| (XVII) | 19269 | 4-[4-(methylsulfanyl)phenyl]-2(5H)-furanone | C11H10O2S | 详情 | 详情 | |
| (XVIII) | 19270 | 3-iodo-4-[4-(methylsulfanyl)phenyl]-2(5H)-furanone | C11H9IO2S | 详情 | 详情 | |
| (XIX) | 16593 | Phenylboronic acid；Benzeneboronic acid;Phenylboron dihydroxide | 98-80-6 | C6H7BO2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(III)The bromination of 3-ethoxy-2-cyclopenten-1-one (I) with Br2 and triethylamine in chloroform gives the 2-bromo derivative (II), which is condensed with 4-bromothioanisole (III) by means of BuLi in THF yielding 2-bromo-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one (IV). The oxidation of (IV) with Na2WO4 and H2O2 affords the corresponding sulfone (V), which is finally condensed with lithium diisopropyl 3-pyridylboronate (VII) or the corresponding dimethyl ester (VIII) by means of tris(dibenzylideneacetone)dipalladium (III) (Pd2(dba)3) and triphenylphosphine in toluene/propanol/water. The lithium boronates (VII) and (VIII) have been obtained by reaction of 3-bromopyridine (VI) with triisopropyl borate or trimethyl borate and BuLi in ethyl ether.
| 【1】 Chan, C.-C.; Brideau, C.; Black, W.C.; et al.; 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. J Med Chem 1999, 42, 7, 1274. |
| 【2】 Black, C.; Hughes, G.; Wang, Z. (Merck Frosst Canada Inc.); Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors. EP 0900201; JP 2000509032; US 5922742; WO 9740012 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25959 | 3-ethoxy-2-cyclopenten-1-one | C7H10O2 | 详情 | 详情 | |
| (II) | 25960 | 2-bromo-3-ethoxy-2-cyclopenten-1-one | C7H9BrO2 | 详情 | 详情 | |
| (III) | 19266 | 4-bromophenyl methyl sulfide; 1-bromo-4-(methylsulfanyl)benzene | 104-95-0 | C7H7BrS | 详情 | 详情 |
| (IV) | 25957 | 2-bromo-3-[4-(methylsulfanyl)phenyl]-2-cyclopenten-1-one | C12H11BrOS | 详情 | 详情 | |
| (V) | 25958 | 2-bromo-3-[4-(methylsulfonyl)phenyl]-2-cyclopenten-1-one | C12H11BrO3S | 详情 | 详情 | |
| (VI) | 13265 | 3-Bromopyridine | 626-55-1 | C5H4BrN | 详情 | 详情 |
| (VII) | 30005 | Triisopropoxy(3-pyridyl)boranuide lithium salt | C14H25BLiNO3 | 详情 | 详情 | |
| (VIII) | 30006 | Trimethoxy(3-pyridyl)boranuide lithium salt | C8H13BLiNO3 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VII)Diazotization of 3,4-difluoroaniline (I), followed by reduction with SnCl2 gives rise to hydrazine (II). This is then condensed with mucobromic acid (III) in refluxing AcOH to produce the pyridazinone (IV). Selective displacement of the 4-bromo of (IV) with the sodium alkoxide of 3-methyl-1,3-butanediol (V) yields ether (VI). 4-(Methylsulfanyl)benzeneboronic acid (VIII) is prepared by metalation of 4-bromothioanisole (VII) with butyl lithium, followed by reaction with trimethyl borate, and aqueous work-up. Suzuki coupling of boronic acid (VIII) with bromopyridazinone (VI) furnishes the 5-(methylsufanylphenyl)pyridazinone (IX). Finally, the sulfide group of (IX) is oxidized to the target sulfone by using peracetic acid in cold dichloromethane.
| 【1】 Stewart, A.O.; Black, L.A.; Basha, A.; Patel, M.V.; Kolasa, T.; Coghlan, M.J.; Liu, H.; Kort, M.E.; McCarty, C.M.; Rohde, J.J. (Abbott Laboratories Inc.); Prostaglandin endoperoxide H synthase biosynthesis inhibitors. EP 1124804; JP 2003512292; WO 0024719 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13451 | 3,4-Difluoroaniline; 3,4-Difluorophenylamine | 3863-11-4 | C6H5F2N | 详情 | 详情 |
| (II) | 61025 | 1-(3,4-difluorophenyl)hydrazine | C6H6F2N2 | 详情 | 详情 | |
| (III) | 22280 | (Z)-2,3-dibromo-4-oxo-2-butenoic acid | 21577-50-4 | C4H2Br2O3 | 详情 | 详情 |
| (IV) | 61026 | 4,5-dibromo-2-(3,4-difluorophenyl)-3(2H)-pyridazinone | C10H4Br2F2N2O | 详情 | 详情 | |
| (V) | 61027 | 3-methyl-1,3-butanediol | C5H12O2 | 详情 | 详情 | |
| (VI) | 61028 | 5-bromo-2-(3,4-difluorophenyl)-4-(3-hydroxy-3-methylbutoxy)-3(2H)-pyridazinone | C15H15BrF2N2O3 | 详情 | 详情 | |
| (VII) | 19266 | 4-bromophenyl methyl sulfide; 1-bromo-4-(methylsulfanyl)benzene | 104-95-0 | C7H7BrS | 详情 | 详情 |
| (VIII) | 18561 | 4-(methylsulfanyl)phenylboronic acid | 98546-51-1 | C7H9BO2S | 详情 | 详情 |
| (IX) | 61029 | 2-(3,4-difluorophenyl)-4-(3-hydroxy-3-methylbutoxy)-5-[4-(methylsulfanyl)phenyl]-3(2H)-pyridazinone | C22H22F2N2O3S | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)4-Bromothioanisole (I) is converted into the corresponding Grignard reagent (II), which is subsequently condensed with N-Cbz-alanine morpholide (III) to furnish the N-Cbz aminoketone (IV). Keto group reduction in (IV) by means of NaBH4, followed by intramolecular cyclization in boiling toluene leads to the chiral oxazolidinone (V). After oxidation of the methylsulfanyl group of (V) to the corresponding sulfone (VI), N-alkylation with the iodobutyl diazepinone (VII) in the presence of potassium tert-amyloxide furnishes adduct (VIII). The oxazolidinone ring of (VIII) is then subjected to reductive cleavage under transfer hydrogenation conditions to produce the secondary amine (IX). Conversion of amine (IX) into the N-propyl derivative (X) is effected by reductive alkylation with propionaldehyde in the presence of NaBH(OAc)3. The N-Boc group of (X) is finally cleaved under acidic conditions to afford the title compound.
| 【1】 Maag, H.; Fisher, L.E.; Prince, A.; Repke, D.B.; Dvorak, C.A.; Harris, R.N. III; Green, K.L.; Stabler, R.S. (F. Hoffmann-La Roche AG); Substd. 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists. JP 2003534330; US 2002004501; US 6667301; WO 0190081 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19266 | 4-bromophenyl methyl sulfide; 1-bromo-4-(methylsulfanyl)benzene | 104-95-0 | C7H7BrS | 详情 | 详情 |
| (II) | 54517 | bromo[4-(methylsulfanyl)phenyl]magnesium | C7H7BrMgS | 详情 | 详情 | |
| (III) | 64406 | benzyl (1S)-1-methyl-2-(4-morpholinyl)-2-oxoethylcarbamate | C15H20N2O4 | 详情 | 详情 | |
| (IV) | 64407 | benzyl (1S)-1-methyl-2-[4-(methylsulfanyl)phenyl]-2-oxoethylcarbamate | C18H19NO3S | 详情 | 详情 | |
| (V) | 64408 | (4S)-4-methyl-5-[4-(methylsulfanyl)phenyl]-1,3-oxazolidin-2-one | C11H13NO2S | 详情 | 详情 | |
| (VI) | 64409 | (4S)-4-methyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidin-2-one | C11H13NO4S | 详情 | 详情 | |
| (VII) | 64410 | tert-butyl 4-(4-iodobutyl)-5-oxo-1,4-diazepane-1-carboxylate | C14H25IN2O3 | 详情 | 详情 | |
| (VIII) | 64411 | tert-butyl 4-(4-{(4S)-4-methyl-5-[4-(methylsulfonyl)phenyl]-2-oxo-1,3-oxazolidin-3-yl}butyl)-5-oxo-1,4-diazepane-1-carboxylate | C25H37N3O7S | 详情 | 详情 | |
| (IX) | 64412 | tert-butyl 4-[4-({(1S)-1-methyl-2-[4-(methylsulfonyl)phenyl]ethyl}amino)butyl]-5-oxo-1,4-diazepane-1-carboxylate | C24H39N3O5S | 详情 | 详情 | |
| (X) | 64405 | tert-butyl 4-{4-[{(1S)-1-methyl-2-[4-(methylsulfonyl)phenyl]ethyl}(propyl)amino]butyl}-5-oxo-1,4-diazepane-1-carboxylate | C27H45N3O5S | 详情 | 详情 |