4-[3-(3-chlorophenyl)-3-oxo-1-phenylpropyl]-3,4-dihydro-1H-1-benzazepine-2,5-dione -Drug Synthesis Database

【结构式】

【分子编号】18881

【品名】4-[3-(3-chlorophenyl)-3-oxo-1-phenylpropyl]-3,4-dihydro-1H-1-benzazepine-2,5-dione

【CA登记号】

【分子式】C₂₅H₂₀ClNO₃

【分子量】417.89144

【元素组成】C 71.85% H 4.82% Cl 8.48% N 3.35% O 11.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Benzazepinedione (I) was condensed with propenone (II) in the presence of a catalytic amount of KOH in ethanol to furnish a diasteromeric mixture of the Michael adducts (III). This mixture was then cyclized and oxidized by means of ammonium ferric sulfate and ammonium acetate in refluxing acetic acid to provide the desired pyridobenzazepinone.

参考文献中间体

合成目标

【1】 Link, A.; Kunick, C.; d-Fused[1]benzazepines with selective in vitro antitumor activity: Synthesis and structure-activity relationships. J Med Chem 1998, 41, 8, 1299.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18879	3,4-dihydro-1H-1-benzazepine-2,5-dione		C₁₀H₉NO₂	详情	详情
(II)	18880	(E)-1-(3-chlorophenyl)-3-phenyl-2-propen-1-one	20426-48-6	C₁₅H₁₁ClO	详情	详情
(III)	18881	4-[3-(3-chlorophenyl)-3-oxo-1-phenylpropyl]-3,4-dihydro-1H-1-benzazepine-2,5-dione		C₂₅H₂₀ClNO₃	详情	详情

Extended Information