-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】2-(3-Chlorophenyl)-4-phenyl-6,7-dihydro-5H-pyrido-[3,2-d][1]benzazepin-6-one

【CA登记号】

【分子式】C₂₅H₁₇ClN₂O

【分子量】396.88004

【开发单位】Univ. Hamburg, Hamburg (DE)

【药理作用】ONCOLYTIC DRUGS, MISCELLANEOUS ANTINEOPLASTIC AGENTS

合成路线1

Benzazepinedione (I) was condensed with propenone (II) in the presence of a catalytic amount of KOH in ethanol to furnish a diasteromeric mixture of the Michael adducts (III). This mixture was then cyclized and oxidized by means of ammonium ferric sulfate and ammonium acetate in refluxing acetic acid to provide the desired pyridobenzazepinone.

参考文献中间体

【1】 Link, A.; Kunick, C.; d-Fused[1]benzazepines with selective in vitro antitumor activity: Synthesis and structure-activity relationships. J Med Chem 1998, 41, 8, 1299.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18879	3,4-dihydro-1H-1-benzazepine-2,5-dione		C₁₀H₉NO₂	详情	详情
(II)	18880	(E)-1-(3-chlorophenyl)-3-phenyl-2-propen-1-one	20426-48-6	C₁₅H₁₁ClO	详情	详情
(III)	18881	4-[3-(3-chlorophenyl)-3-oxo-1-phenylpropyl]-3,4-dihydro-1H-1-benzazepine-2,5-dione		C₂₅H₂₀ClNO₃	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)