N-[1-(3-methoxyphenyl)ethyl]-N-(3-phenylpropyl)amine; N-[1-(3-methoxyphenyl)ethyl]-3-phenyl-1-propanamine -Drug Synthesis Database

【结构式】

【分子编号】18793

【品名】N-[1-(3-methoxyphenyl)ethyl]-N-(3-phenylpropyl)amine; N-[1-(3-methoxyphenyl)ethyl]-3-phenyl-1-propanamine

【CA登记号】

【分子式】C₁₈H₂₃NO

【分子量】269.38676

【元素组成】C 80.26% H 8.61% N 5.2% O 5.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Title compound was prepared by reductive alkylation of 3-phenylpropylamine (I) with 3'-methoxyacetophenone (II) using NaCNBH3 in the presence of titanium isopropoxide in EtOH. Subsequent chiral resolution of the resulting secondary amine (III) by chromatography on ChiralCel OD provided the desired R-enantiomer.

参考文献中间体

合成目标

【1】 Nemeth, E.F.; Van Wagenen, B.C.; Balandrin, M.F. (NPS Pharmaceuticals, Inc.); Calcium receptor active molecules. WO 9304373 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18791	3-phenylpropylamine; 3-phenyl-1-propanamine	2038-57-5	C₉H₁₃N	详情	详情
(II)	18792	3-methoxyacetophenone; 1-(3-methoxyphenyl)-1-ethanone	586-37-8	C₉H₁₀O₂	详情	详情
(III)	18793	N-[1-(3-methoxyphenyl)ethyl]-N-(3-phenylpropyl)amine; N-[1-(3-methoxyphenyl)ethyl]-3-phenyl-1-propanamine		C₁₈H₂₃NO	详情	详情

Extended Information