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【结 构 式】 
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【药物名称】NPS-467 【化学名称】N-[1(R)-(3-Methoxyphenyl)ethyl]-3-phenyl-1-propanamine 【CA登记号】 【 分 子 式 】C18H23NO 【 分 子 量 】269.39011 |
【开发单位】NPS Pharm 【药理作用】THYROID DISEASE THERAPY |
合成路线1
Title compound was prepared by reductive alkylation of 3-phenylpropylamine (I) with 3'-methoxyacetophenone (II) using NaCNBH3 in the presence of titanium isopropoxide in EtOH. Subsequent chiral resolution of the resulting secondary amine (III) by chromatography on ChiralCel OD provided the desired R-enantiomer.
| 【1】 Nemeth, E.F.; Van Wagenen, B.C.; Balandrin, M.F. (NPS Pharmaceuticals, Inc.); Calcium receptor active molecules. WO 9304373 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18791 | 3-phenylpropylamine; 3-phenyl-1-propanamine | 2038-57-5 | C9H13N | 详情 | 详情 |
| (II) | 18792 | 3-methoxyacetophenone; 1-(3-methoxyphenyl)-1-ethanone | 586-37-8 | C9H10O2 | 详情 | 详情 |
| (III) | 18793 | N-[1-(3-methoxyphenyl)ethyl]-N-(3-phenylpropyl)amine; N-[1-(3-methoxyphenyl)ethyl]-3-phenyl-1-propanamine | C18H23NO | 详情 | 详情 |
Extended Information