3-(2-formyl-4-methyl-1H-pyrrol-3-yl)propionic acid -Drug Synthesis Database

【结构式】

【分子编号】18700

【品名】3-(2-formyl-4-methyl-1H-pyrrol-3-yl)propionic acid

【CA登记号】132281-87-9

【分子式】C₉H₁₁NO₃

【分子量】181.19128

【元素组成】C 59.66% H 6.12% N 7.73% O 26.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Title compound was prepared by condensation of oxindole (I) and formylpyrrole (II) in the presence of a catalytic amount of piperidine in refluxing EtOH.

参考文献中间体

合成目标

【1】 Tang, P.C.; Sun, L.; McMahon, G. (Sugen, Inc.); Indolinone cpds. for the treatment of disease. EP 0769947; JP 2000026412; US 5780496; US 5792783; US 5880141; US 5883113; US 5883116; WO 9640116 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18699	1,3-dihydro-2H-indol-2-one	59-48-3	C₈H₇NO	详情	详情
(II)	18700	3-(2-formyl-4-methyl-1H-pyrrol-3-yl)propionic acid	132281-87-9	C₉H₁₁NO₃	详情	详情

Extended Information