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【结 构 式】 
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【药物名称】SU-5402 【化学名称】(Z)-3-[4-Methyl-2-(2-oxo-3,4-dihydroindol-3-ylmethylene)- pyrrol-3-yl]propionic acid 【CA登记号】 【 分 子 式 】C17H16N2O3 【 分 子 量 】296.32867 |
【开发单位】Sugen 【药理作用】ONCOLYTIC DRUGS，INHIBITORS OF SIGNAL TRANSDUCTION PATHWAYS |
合成路线1
Title compound was prepared by condensation of oxindole (I) and formylpyrrole (II) in the presence of a catalytic amount of piperidine in refluxing EtOH.
| 【1】 Tang, P.C.; Sun, L.; McMahon, G. (Sugen, Inc.); Indolinone cpds. for the treatment of disease. EP 0769947; JP 2000026412; US 5780496; US 5792783; US 5880141; US 5883113; US 5883116; WO 9640116 . |
Extended Information