【结 构 式】 |
【分子编号】18618 【品名】2-[10-[(6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-1H-isoindole-1,3(2H)-dione 【CA登记号】 |
【 分 子 式 】C34H42N2O5 【 分 子 量 】558.71796 【元素组成】C 73.09% H 7.58% N 5.01% O 14.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)Alkylation of potassium phthalimide (I) with an excess of 1,10-dibromodecane (II) in refluxing acetone afforded N-(10-bromodecyl)phthalimide (III). This was condensed with 6-O-demethylgalanthamine (IV) in the presence of Et3N in boiling acetonitrile to give phthalimidodecyl compound (V). Finally, reaction with N-bromosuccinimide in the presence of azobisisobutyronitrile provided the iminium bromide.
【1】 Mary, A.; Renko, D.Z.; Guillou, C.; Thal, C.; Potent acetylcholinesterase inhibitors: Design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series. Bioorg Med Chem 1998, 6, 10, 1835. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 10929 | 3-Ethyl-7-methyl-3,7-diazabicyclo[3.3.1]nonan-9-one | C10H18N2O | 详情 | 详情 | |
(II) | 18615 | 1,10-dibromodecane | 4101-68-2 | C10H20Br2 | 详情 | 详情 |
(III) | 18616 | 2-(10-bromodecyl)-1H-isoindole-1,3(2H)-dione | 24566-80-1 | C18H24BrNO2 | 详情 | 详情 |
(IV) | 18612 | (6R,8aS)-3-methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol | C16H19NO3 | 详情 | 详情 | |
(V) | 18618 | 2-[10-[(6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-1H-isoindole-1,3(2H)-dione | C34H42N2O5 | 详情 | 详情 |
Extended Information