• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】18616

【品名】2-(10-bromodecyl)-1H-isoindole-1,3(2H)-dione

【CA登记号】24566-80-1

【 分 子 式 】C18H24BrNO2

【 分 子 量 】366.2981

【元素组成】C 59.02% H 6.6% Br 21.81% N 3.82% O 8.74%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Alkylation of potassium phthalimide (I) with an excess of 1,10-dibromodecane (II) in refluxing acetone afforded N-(10-bromodecyl)phthalimide (III). This was condensed with 6-O-demethylgalanthamine (IV) in the presence of Et3N in boiling acetonitrile to give phthalimidodecyl compound (V). Finally, reaction with N-bromosuccinimide in the presence of azobisisobutyronitrile provided the iminium bromide.

1 Mary, A.; Renko, D.Z.; Guillou, C.; Thal, C.; Potent acetylcholinesterase inhibitors: Design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series. Bioorg Med Chem 1998, 6, 10, 1835.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10929 3-Ethyl-7-methyl-3,7-diazabicyclo[3.3.1]nonan-9-one C10H18N2O 详情 详情
(II) 18615 1,10-dibromodecane 4101-68-2 C10H20Br2 详情 详情
(III) 18616 2-(10-bromodecyl)-1H-isoindole-1,3(2H)-dione 24566-80-1 C18H24BrNO2 详情 详情
(IV) 18612 (6R,8aS)-3-methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol C16H19NO3 详情 详情
(V) 18618 2-[10-[(6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-1H-isoindole-1,3(2H)-dione C34H42N2O5 详情 详情
Extended Information