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【结 构 式】 
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【分子编号】27086 【品名】5,7-dimethoxy-2-(2-methylphenyl)-4-quinolinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C19H17NO4 【 分 子 量 】323.34832 【元素组成】C 70.58% H 5.3% N 4.33% O 19.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Quinoline (IV) was prepared by condensation of 3,5-dimethoxyaniline (I), pyruvic acid (II) and o-tolualdehyde (III) in refluxing EtOH. After activation of (IV) as the acid chloride (V) by means of SOCl2 in benzene, its condensation with guanidine (VI) in DMF yielded the corresponding acyl guanidine.
| 【1】 Fujiwara, J.; Mori, H.; Yamashita, H.; Kitamori, T.; Hosoya, J.; Banno, H. (Mitsui Chemicals, Inc.); Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical compsns. containing the cpds.. EP 0726254; JP 1996277269; US 5627193 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25780 | 3,5-dimethoxyaniline; 3,5-dimethoxyphenylamine | 10272-07-8 | C8H11NO2 | 详情 | 详情 |
| (II) | 24066 | 2-oxopropionic acid | 127-17-3 | C3H4O3 | 详情 | 详情 |
| (III) | 27085 | 2-methylbenzaldehyde | 529-20-4 | C8H8O | 详情 | 详情 |
| (IV) | 27086 | 5,7-dimethoxy-2-(2-methylphenyl)-4-quinolinecarboxylic acid | C19H17NO4 | 详情 | 详情 | |
| (V) | 27087 | 5,7-dimethoxy-2-(2-methylphenyl)-4-quinolinecarbonyl chloride | C19H16ClNO3 | 详情 | 详情 | |
| (VI) | 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 |
Extended Information