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【结 构 式】 
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【药物名称】MS-31-050 【化学名称】N1-[5,7-Dimethoxy-2-(2-methylphenyl)quinolin-4-ylcarbonyl]guanidine dihydrochloride 【CA登记号】181048-29-3 (free base) 【 分 子 式 】C20H22Cl2N4O3 【 分 子 量 】437.32934 |
【开发单位】Mitsui Chemicals (Originator) 【药理作用】Angina pectoris, Treatment of, Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Na+/H+ Exchange (NHE) Inhibitors |
合成路线1
Quinoline (IV) was prepared by condensation of 3,5-dimethoxyaniline (I), pyruvic acid (II) and o-tolualdehyde (III) in refluxing EtOH. After activation of (IV) as the acid chloride (V) by means of SOCl2 in benzene, its condensation with guanidine (VI) in DMF yielded the corresponding acyl guanidine.
| 【1】 Fujiwara, J.; Mori, H.; Yamashita, H.; Kitamori, T.; Hosoya, J.; Banno, H. (Mitsui Chemicals, Inc.); Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical compsns. containing the cpds.. EP 0726254; JP 1996277269; US 5627193 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25780 | 3,5-dimethoxyaniline; 3,5-dimethoxyphenylamine | 10272-07-8 | C8H11NO2 | 详情 | 详情 |
| (II) | 24066 | 2-oxopropionic acid | 127-17-3 | C3H4O3 | 详情 | 详情 |
| (III) | 27085 | 2-methylbenzaldehyde | 529-20-4 | C8H8O | 详情 | 详情 |
| (IV) | 27086 | 5,7-dimethoxy-2-(2-methylphenyl)-4-quinolinecarboxylic acid | C19H17NO4 | 详情 | 详情 | |
| (V) | 27087 | 5,7-dimethoxy-2-(2-methylphenyl)-4-quinolinecarbonyl chloride | C19H16ClNO3 | 详情 | 详情 | |
| (VI) | 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 |
Extended Information