【结 构 式】 |
【分子编号】25883 【品名】4-(2-quinolinylmethoxy)benzaldehyde 【CA登记号】 |
【 分 子 式 】C17H13NO2 【 分 子 量 】263.29576 【元素组成】C 77.55% H 4.98% N 5.32% O 12.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)By condensation of 4-(2-quinolinylmethoxy)benzaldeyde (I) with 2-hydroxy-5(1H-tetrazol-5-yl)acetophenone (II) by means of KOH in ethanol/water. The intermediates (I) and (II) have been obtained as follows: Benzaldehyde (I): By condensation of 2-(chloromethyl)quinoline (III) with 4-hydroxybenzaldehyde (IV) by means of K2CO3 in hot DMF. Acetophenone (II): The acetylation of 4-hydroxybenzonitrile (V) with acetic anhydride/sulfuric acid and AlCl3 gives 5-cyano-2-hydroxyacetophenone (VI), which is then cyclized with sodium azide and ammonium chloride in hot DMF.
【1】 Zwaagstra, M.E.; et al.; Synthesis and structure - activity relationships of carboxylated chalcones: A novel series of CysLT1 (LTD4) receptor antagonists. J Med Chem 1997, 40, 7, 1075. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25883 | 4-(2-quinolinylmethoxy)benzaldehyde | C17H13NO2 | 详情 | 详情 | |
(II) | 25884 | 1-[2-hydroxy-5-(1H-1,2,3,4-tetraazol-5-yl)phenyl]-1-ethanone | C9H8N4O2 | 详情 | 详情 | |
(III) | 13162 | 2-(Chloromethyl)quinoline; alpha-Chloroquinaldine | 4377-41-7 | C10H8ClN | 详情 | 详情 |
(IV) | 13433 | 4-Hydroxybenzaldehyde; p-Hydroxybenzaldehyde | 123-08-0 | C7H6O2 | 详情 | 详情 |
(V) | 25109 | 4-hydroxybenzonitrile | 767-00-0 | C7H5NO | 详情 | 详情 |
(VI) | 12857 | 3-Acetyl-4-hydroxybenzonitrile | C9H7NO2 | 详情 | 详情 |
Extended Information