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【结 构 式】 
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【药物名称】VUF-4819 【化学名称】1-[2-Hydroxy-5-(1H-tetrazol-5-yl)phenyl]-3-[4-(quinolin-2-ylmethoxy)phenyl]-2(E)-propen-1-one 【CA登记号】187272-44-2 【 分 子 式 】C26H19N5O3 【 分 子 量 】449.47303 |
【开发单位】Kowa (Originator), Vrije Universiteit (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Leukotriene Antagonists, Leukotriene CysLT1 (LTD4) Antagonists |
合成路线1
By condensation of 4-(2-quinolinylmethoxy)benzaldeyde (I) with 2-hydroxy-5(1H-tetrazol-5-yl)acetophenone (II) by means of KOH in ethanol/water. The intermediates (I) and (II) have been obtained as follows: Benzaldehyde (I): By condensation of 2-(chloromethyl)quinoline (III) with 4-hydroxybenzaldehyde (IV) by means of K2CO3 in hot DMF. Acetophenone (II): The acetylation of 4-hydroxybenzonitrile (V) with acetic anhydride/sulfuric acid and AlCl3 gives 5-cyano-2-hydroxyacetophenone (VI), which is then cyclized with sodium azide and ammonium chloride in hot DMF.
| 【1】 Zwaagstra, M.E.; et al.; Synthesis and structure - activity relationships of carboxylated chalcones: A novel series of CysLT1 (LTD4) receptor antagonists. J Med Chem 1997, 40, 7, 1075. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25883 | 4-(2-quinolinylmethoxy)benzaldehyde | C17H13NO2 | 详情 | 详情 | |
| (II) | 25884 | 1-[2-hydroxy-5-(1H-1,2,3,4-tetraazol-5-yl)phenyl]-1-ethanone | C9H8N4O2 | 详情 | 详情 | |
| (III) | 13162 | 2-(Chloromethyl)quinoline; alpha-Chloroquinaldine | 4377-41-7 | C10H8ClN | 详情 | 详情 |
| (IV) | 13433 | 4-Hydroxybenzaldehyde; p-Hydroxybenzaldehyde | 123-08-0 | C7H6O2 | 详情 | 详情 |
| (V) | 25109 | 4-hydroxybenzonitrile | 767-00-0 | C7H5NO | 详情 | 详情 |
| (VI) | 12857 | 3-Acetyl-4-hydroxybenzonitrile | C9H7NO2 | 详情 | 详情 |