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【结 构 式】 
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【分子编号】24602 【品名】2-amino-N-hydroxyacetamide 【CA登记号】 |
【 分 子 式 】C2H6N2O2 【 分 子 量 】90.08192 【元素组成】C 26.67% H 6.71% N 31.1% O 35.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Ethyl glycinate (I) was converted to the 2-aminoacetohydroxamic acid (II) by reaction with hydroxylamine in the presence of KOH in aqueous MeOH. Subsequent cyclization of (II) upon treatment with formaldehyde provided the target 3-hydroxyimidazolin-4-one.
| 【1】 Audinot, V.; Millan, M.; Cordi, A.; Lacoste, J.-M.; Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett 1999, 9, 10, 1409. |
| 【2】 Cordi, A.; Lacoste, J.-M.; Millan, M.; Audinot, V. (ADIR et Cie.); 4-Imidazolidinone cpds.. EP 0780379; US 5677325 . |
Extended Information