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【结 构 式】 
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【药物名称】S-18841 【化学名称】3-Hydroxyimidazolidin-4-one 【CA登记号】192565-05-2 【 分 子 式 】C3H6N2O2 【 分 子 量 】102.09347 |
【开发单位】ADIR (Originator) 【药理作用】Antipsychotic Drugs, PSYCHOPHARMACOLOGIC DRUGS, NMDA Glycine-Site Agonists |
合成路线1
Ethyl glycinate (I) was converted to the 2-aminoacetohydroxamic acid (II) by reaction with hydroxylamine in the presence of KOH in aqueous MeOH. Subsequent cyclization of (II) upon treatment with formaldehyde provided the target 3-hydroxyimidazolin-4-one.
| 【1】 Audinot, V.; Millan, M.; Cordi, A.; Lacoste, J.-M.; Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett 1999, 9, 10, 1409. |
| 【2】 Cordi, A.; Lacoste, J.-M.; Millan, M.; Audinot, V. (ADIR et Cie.); 4-Imidazolidinone cpds.. EP 0780379; US 5677325 . |
Extended Information