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【结 构 式】 
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【分子编号】17609 【品名】ethyl 2-methyl-2-phenylpropanoate 【CA登记号】 |
【 分 子 式 】C12H16O2 【 分 子 量 】192.25784 【元素组成】C 74.97% H 8.39% O 16.64% |
合成路线1
该中间体在本合成路线中的序号：(XIV)1) The reduction of 2-methyl-2-phenylpropionic acid with LiAlH4 in THF gives 2-methyl-2-phenyl-1-propanol (II), which is acetylated with acetic anhydride in pyridine yielding the acetate (III). The Friedel-Crafts condensation of (III) with 4-chlorobutyryl chloride (IV) by means of AlCl3 in dichloromethane affords the butyrophenone (V), which is condensed with alpha,alpha-diphenylipiperidine-4-methanol (VI) by means of KHCO3 and KI in refluxing toluene/water to give the butyrophenone (VII). The deacetylation of (VII) with NaOH in refluxing methanol yields the primary alcohol (VIII), which is oxidized with oxalyl chloride and DMSO in methylene chloride to the corresponding aldehyde (IX). The oxidation of (IX) with KMnO4 in acetone affords the ketoacid (X), which is finally reduced with NaBH4 in water. 2) The acetate (III) can also be obtained by Friedel-Crafts condensation of 2-methyl-2-propenyl acetate (XI) with refluxing benzene (XII) by means of AlCl3. 3) The ketoacid (X) can also be obtained by direct oxidation of the primary alcohol (VIII) with H5IO6 in chloroform/acetonitrile, or K2S2O8 in acetone/acetonitrile, both catalyzed by RuCl3.5H2O.
| 【1】 Graul, A.; Castañer, J.; Fexofenadine Hydrochloride. Drugs Fut 1996, 21, 10, 1017. |
| 【2】 King, C.-H.; Kaminski, M.A. (Merrell Pharmaceuticals, Inc.); 4-Diphenylmethyl piperidine derivs. and process for their preparation. JP 1996502022; WO 9321156 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17173 | 2-Methyl-2-phenylpropionic acid; 2-Methyl-2-phenyl-propionic acid | 826-55-1 | C10H12O2 | 详情 | 详情 |
| (II) | 17174 | 2-methyl-2-phenyl-1-propanol | C10H14O | 详情 | 详情 | |
| (III) | 17175 | 2-methyl-2-phenylpropyl acetate | 2901-13-5 | C12H16O2 | 详情 | 详情 |
| (IV) | 11265 | 4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride | 4635-59-0 | C4H6Cl2O | 详情 | 详情 |
| (V) | 17177 | 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropyl acetate | C16H21ClO3 | 详情 | 详情 | |
| (VI) | 17178 | diphenyl(4-piperidinyl)methanol; alpha,alpha-Diphenyl-4-piperidinomethanol; Azacyclonol | 115-46-8 | C18H21NO | 详情 | 详情 |
| (VII) | 17179 | 2-[4-(4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butanoyl)phenyl]-2-methylpropyl acetate | 76811-96-6 | C34H41NO4 | 详情 | 详情 |
| (VIII) | 17180 | 1-[4-(2-hydroxy-1,1-dimethylethyl)phenyl]-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-1-butanone | C32H39NO3 | 详情 | 详情 | |
| (IX) | 17181 | 2-[4-(4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butanoyl)phenyl]-2-methylpropanal | C32H37NO3 | 详情 | 详情 | |
| (X) | 17182 | 2-[4-(4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butanoyl)phenyl]-2-methylpropionic acid | 76811-98-8 | C32H37NO4 | 详情 | 详情 |
| (XI) | 17183 | 2-methyl-2-propenyl acetate；methallyl acetate | 820-71-3 | C6H10O2 | 详情 | 详情 |
| (XII) | 13364 | Benzene | 71-43-2 | C6H6 | 详情 | 详情 |
| (XIV) | 17609 | ethyl 2-methyl-2-phenylpropanoate | C12H16O2 | 详情 | 详情 | |
| (XV) | 17610 | ethyl 2-[4-(cyclopropylcarbonyl)phenyl]-2-methylpropanoate | C16H20O3 | 详情 | 详情 | |
| (XVI) | 17611 | ethyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate | C16H21ClO3 | 详情 | 详情 | |
| (XVII) | 17612 | ethyl 2-[4-(4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butanoyl)phenyl]-2-methylpropanoate | C34H41NO4 | 详情 | 详情 | |
| (XVIII) | 17613 | ethyl 2-[4-(1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl)phenyl]-2-methylpropanoate | C34H43NO4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XIV)4) The Friedel-Crafts condensation of cyclopropylcarbonyl chloride (XIII) with 2-methyl-2-phenylpropionic acid ethyl ester (XIV) gives 2-[4-(cyclopropylcarbonyl)phenyl]-2-methylpropionic acid ethyl ester (XV), which by reaction with dry HCl in hot acetonitrile yields the 4-chlorobutyryl derivative (XVI). The condensation of (XVI) with the piperidine (VI) by means of KHCO3 affords the omega-piperidylbutyrophenone (XVII), which is reduced with NaBH4 in methanol to give the dihydroxy ester (XVIII). Finally, this compound is saponified with NaOH in refluxing methanol. 5) The chlorobutyryl derivative (XVI) can also be obtained by direct Friedel-Crafts condensation of propionic ester (XIV) with 4-chlorobutyryl chloride (IV) by means of AlCl3 as before.
| 【1】 Graul, A.; Castañer, J.; Fexofenadine Hydrochloride. Drugs Fut 1996, 21, 10, 1017. |
| 【2】 Krauss, R.C.; Strom, R.M.; Scortichini, C.L.; Kruper, W.J.; Wolf, R.A.; Carr, A.A.; Rudisill, D.E.; Panzone, G.; Hay, D.A.; Wu, W.W. (Merrell Pharmaceuticals, Inc.); Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivs. WO 9500480 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 11265 | 4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride | 4635-59-0 | C4H6Cl2O | 详情 | 详情 |
| (VI) | 17178 | diphenyl(4-piperidinyl)methanol; alpha,alpha-Diphenyl-4-piperidinomethanol; Azacyclonol | 115-46-8 | C18H21NO | 详情 | 详情 |
| (XIII) | 14061 | Cyclopropanecarbonyl chloride; Cyclopropanecarboxylic acid chloride | 4023-34-1 | C4H5ClO | 详情 | 详情 |
| (XIV) | 17609 | ethyl 2-methyl-2-phenylpropanoate | C12H16O2 | 详情 | 详情 | |
| (XV) | 17610 | ethyl 2-[4-(cyclopropylcarbonyl)phenyl]-2-methylpropanoate | C16H20O3 | 详情 | 详情 | |
| (XVI) | 17611 | ethyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate | C16H21ClO3 | 详情 | 详情 | |
| (XVII) | 17612 | ethyl 2-[4-(4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butanoyl)phenyl]-2-methylpropanoate | C34H41NO4 | 详情 | 详情 | |
| (XVIII) | 17613 | ethyl 2-[4-(1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl)phenyl]-2-methylpropanoate | C34H43NO4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)Ethyl phenylacetate (I) was alkylated with two equivalents of methyl iodide in the presence of potassium tert-butoxide to yield 2-methyl-2-phenylpropionic ester (II), which was reduced to alcohol (III) with LiAlH4. The alcohol function of (III) was esterified with Ac2O in pyridine, and the resulting compound (IV) was converted to sulfonyl chloride (V) by sulfonation with H2SO4, followed by treatment with SOCl2. Further reaction of (V) with ammonium hydroxide yielded sulfonamide (VI). Condensation of this sulfonamide with the dichloropyrimidine (VII) furnished, after saponification with NaOH, the N-pyrimidinylsulfonamide (VIII)). The alcohol function of (VIII) was then protected as the tetrahydropyranyl ether with dihydropyran and camphorsulfonic acid, and further treatment with the sodium salt of ethylene glycol at 100 C yielded the (2-hydroxyethoxy)pyrimidine (IX). Condensation of (IX) with 5-bromo-2-chloropyrimidine (X) in the presence of NaH gave (XI), which was finally converted to the target compound by acid deprotection of the tetrahydropyranyl acetal, followed by formation of the sodium salt with NaOMe in THF-MeOH.
| 【1】 Yamada, K.; et al.; Syntheses and structure-activity relationships of sulfonamide derivatives as endothelin antagonists: A potent and selective ET-A antagonist, TA-0201 and related compounds. 216th ACS Natl Meet (Aug. 23-27, Boston) 1998, Abst MEDI 057. |
| 【2】 Yamada, K.; Yasuda, K.; Kikkawa, K.; Kohno, R. (Tanabe Seiyaku Co., Ltd.); Benzenesulfonamide deriv. and process for preparing thereof. CA 2137953; EP 0658548; JP 1996099961; US 5589478; US 5728706 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21045 | ethyl 2-phenylacetate | 101-97-3 | C10H12O2 | 详情 | 详情 |
| (II) | 17609 | ethyl 2-methyl-2-phenylpropanoate | C12H16O2 | 详情 | 详情 | |
| (III) | 17174 | 2-methyl-2-phenyl-1-propanol | C10H14O | 详情 | 详情 | |
| (IV) | 17175 | 2-methyl-2-phenylpropyl acetate | 2901-13-5 | C12H16O2 | 详情 | 详情 |
| (V) | 21049 | 2-[4-(chlorosulfonyl)phenyl]-2-methylpropyl acetate | C12H15ClO4S | 详情 | 详情 | |
| (VI) | 21050 | 2-[4-(aminosulfonyl)phenyl]-2-methylpropyl acetate | C12H17NO4S | 详情 | 详情 | |
| (VII) | 21051 | 4,6-dichloro-5-(4-methylphenyl)pyrimidine | C11H8Cl2N2 | 详情 | 详情 | |
| (VIII) | 21052 | N-[6-chloro-5-(4-methylphenyl)-4-pyrimidinyl]-4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide | C21H22ClN3O3S | 详情 | 详情 | |
| (IX) | 21053 | 4-[1,1-dimethyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-N-[6-(2-hydroxyethoxy)-5-(4-methylphenyl)-4-pyrimidinyl]benzenesulfonamide | C28H35N3O6S | 详情 | 详情 | |
| (X) | 21054 | 5-bromo-2-chloropyrimidine | C4H2BrClN2 | 详情 | 详情 | |
| (XI) | 21055 | N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-(4-methylphenyl)-4-pyrimidinyl]-4-[1,1-dimethyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzenesulfonamide | C32H36BrN5O6S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VI)Ethyl phenylacetate (V) was dimethylated upon treatment with iodomethane and sodium bis(trimethylsilyl)amide, yielding (VI). Iodination of (VI) was carried out by means of iodine and sodium iodate in acidic medium, and the resulting iodo ester (VII) was subsequently hydrolyzed with KOH to the carboxylic acid (VIII). This was converted to the tert-butyl ester (X) via conversion to the corresponding acid chloride (IX) with oxalyl chloride, followed by treatment with potassium tert-butoxide. Palladium-catalyzed Heck coupling of aryl iodide (X) with N-Boc-dehydroalanine benzyl ester (XI) furnished the aminocinnamic acid derivative (XII). Then, catalytic hydrogenation of the olefin double bond of (XII) with simultaneous benzyl ester cleavage provided the protected racemic amino acid intermediate (XIII).
| 【1】 Proudfoot, J.R.; et al.; Nonpeptidic, monocharged, cell permeable ligands of the p56lck SH2 domain. J Med Chem 2001, 44, 15, 2421. |
| 【2】 Betageri, R.; Llinas-Brunet, M.; Moss, N.; Patel, U.; Cardozo, M.; Beaulieu, P.L.; Ferland, J.-M.; Proudfoot, J.R. (Boehringer Ingelheim Pharmaceuticals Inc.); Pyridones as Src family SH2 domain inhibitors. EP 1045836; US 6054470; US 6156784; WO 9931066 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 21045 | ethyl 2-phenylacetate | 101-97-3 | C10H12O2 | 详情 | 详情 |
| (VI) | 17609 | ethyl 2-methyl-2-phenylpropanoate | C12H16O2 | 详情 | 详情 | |
| (VII) | 50661 | ethyl 2-(4-iodophenyl)-2-methylpropanoate | C12H15IO2 | 详情 | 详情 | |
| (VIII) | 50662 | 2-(4-iodophenyl)-2-methylpropionic acid | C10H11IO2 | 详情 | 详情 | |
| (IX) | 50663 | 2-(4-iodophenyl)-2-methylpropanoyl chloride | C10H10ClIO | 详情 | 详情 | |
| (X) | 50664 | tert-butyl 2-(4-iodophenyl)-2-methylpropanoate | C14H19IO2 | 详情 | 详情 | |
| (XI) | 50665 | benzyl 2-[(tert-butoxycarbonyl)amino]acrylate | C15H19NO4 | 详情 | 详情 | |
| (XII) | 50666 | benzyl (E)-2-[(tert-butoxycarbonyl)amino]-3-[4-[2-(tert-butoxy)-1,1-dimethyl-2-oxoethyl]phenyl]-2-propenoate | C29H37NO6 | 详情 | 详情 | |
| (XIII) | 50667 | N-(tert-butoxycarbonyl)-4-[2-(tert-butoxy)-1,1-dimethyl-2-oxoethyl]phenylalanine | C22H33NO6 | 详情 | 详情 |