【结 构 式】 |
【分子编号】21492 【品名】[5-[4-amino-2-oxo-1(2H)-pyrimidinyl]-3,4-dihydroxytetrahydro-2-furanyl]methyl dihydrogen phosphate 【CA登记号】63-37-6 |
【 分 子 式 】C9H14N3O8P 【 分 子 量 】323.199342 【元素组成】C 33.45% H 4.37% N 13% O 39.6% P 9.58% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)Acetylation of 1-beta-D-arabinofuranosylcytosine 5'-monophosphate (I) with acetic anhydride gives acetylated compound (II), which is treated with tosyl chloride and stearyl alcohol to synthesize stearyl ester (IV). Stearyl ester (IV) is deacetylated and converted to sodium salt.
【1】 Takahashi, K.; Kodama, K.; YNK01. Drugs Fut 1989, 14, 11, 1056. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 21492 | [5-[4-amino-2-oxo-1(2H)-pyrimidinyl]-3,4-dihydroxytetrahydro-2-furanyl]methyl dihydrogen phosphate | 63-37-6 | C9H14N3O8P | 详情 | 详情 |
(II) | 21493 | 2'-O,3'-O,N4-Triacetyl-1-(5'-O-phosphono-beta-D-arabinosyl)cytosine bis(tributylammonium) salt | C38H74N5O11P | 详情 | 详情 | |
(III) | 21494 | 1-octadecanol | 112-92-5 | C18H38O | 详情 | 详情 |
(IV) | 21495 | N,N-dibutyl-1-butanaminium ([3,4-bis(acetoxy)-5-[4-(methoxyamino)-2-oxo-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methoxy)(octadecyloxy)oxophosphoranolate | C44H83N4O11P | 详情 | 详情 |
Extended Information