|
【结 构 式】 
|
【药物名称】Fosteabine sodium hydrate, Cytarabine ocfosfate, C18PCA, YNK01, Starasid 【化学名称】1-beta-D-Arabinofuranosylcytosine 5'-stearyl phosphate monosodium salt monohydrate 【CA登记号】116459-64-4, 65093-40-5 (anhydrous), 73532-83-9 (anhydrous, free acid) 【 分 子 式 】C27H51N3NaO9P 【 分 子 量 】615.68582 |
【开发单位】Nippon Kayaku (Originator), Asta Medica (Licensee), Yamasa Shoyu (Licensee) 【药理作用】Oncolytic Drugs, Antimetabolites |
合成路线1
Acetylation of 1-beta-D-arabinofuranosylcytosine 5'-monophosphate (I) with acetic anhydride gives acetylated compound (II), which is treated with tosyl chloride and stearyl alcohol to synthesize stearyl ester (IV). Stearyl ester (IV) is deacetylated and converted to sodium salt.
| 【1】 Takahashi, K.; Kodama, K.; YNK01. Drugs Fut 1989, 14, 11, 1056. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21492 | [5-[4-amino-2-oxo-1(2H)-pyrimidinyl]-3,4-dihydroxytetrahydro-2-furanyl]methyl dihydrogen phosphate | 63-37-6 | C9H14N3O8P | 详情 | 详情 |
| (II) | 21493 | 2'-O,3'-O,N4-Triacetyl-1-(5'-O-phosphono-beta-D-arabinosyl)cytosine bis(tributylammonium) salt | C38H74N5O11P | 详情 | 详情 | |
| (III) | 21494 | 1-octadecanol | 112-92-5 | C18H38O | 详情 | 详情 |
| (IV) | 21495 | N,N-dibutyl-1-butanaminium ([3,4-bis(acetoxy)-5-[4-(methoxyamino)-2-oxo-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methoxy)(octadecyloxy)oxophosphoranolate | C44H83N4O11P | 详情 | 详情 |
Extended Information