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【结 构 式】 
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【分子编号】16765 【品名】2-(dimethylamino)acetic acid; N,N-Dimethylglycine 【CA登记号】1118-68-9 |
【 分 子 式 】C4H9NO2 【 分 子 量 】103.121 【元素组成】C 46.59% H 8.8% N 13.58% O 31.03% |
合成路线1
该中间体在本合成路线中的序号：(II)By condensation of partricin A 2-(dimethylamino)ethylamide (I) with N,N-dimethylglycine (II) by means of triethylamine and diphenyl phosphoroazidate (DPAZ) in dimethylacetamide.
| 【1】 Castañer, J.; Fromtling, R.A.; SPA-S-753. Drugs Fut 1997, 22, 8, 846. |
| 【2】 Bruzzese, T.; Signorini, M.; Ottoni, F. (SPA (Societa Prodotti Antibiotici)); Partricin derivs. EP 0489308; US 5298495 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16764 | 33-[[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-N-[2-(dimethylamino)ethyl]-1,3,5,7,9,13,37-heptahydroxy-17-[4-hydroxy-1-methyl-6-[4-(methylamino)phenyl]-6-oxohexyl]-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxamide | C63H96N4O18 | 详情 | 详情 | |
| (II) | 16765 | 2-(dimethylamino)acetic acid; N,N-Dimethylglycine | 1118-68-9 | C4H9NO2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XII)An alternative route was based on the formylation of (III) with dichloromethyl methyl ether (IX) in the presence of tin chloride. The resultant aldehyde ester (X) was then reduced to the already reported diol (VIII) by means of LiBH4. The crude trifluoroacetate ester obtained by treatment of diol (VIII) with trifluoroacetic anhydride was then refluxed with isopropanol to furnish the isopropyl ether (XI). The remaining hydroxyl group was finally esterified by treatment with N,N-dimethylglycine (XII) in the presence of EDC and DMAP.
| 【1】 Hudkins, R.L.; Gingrich, D.E. (Cephalon, Inc.); Selected fused pyrrolocarbazoles. WO 0217914 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 59387 | ethyl 3-(5-oxo-5,6,7,13-tetrahydro-12H-indeno[2,1-a]pyrrolo[3,4-c]carbazol-12-yl)propanoate | C26H22N2O3 | 详情 | 详情 | |
| (VIII) | 59392 | 9-(hydroxymethyl)-12-(3-hydroxypropyl)-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[3,4-c]carbazol-5-one | C25H22N2O3 | 详情 | 详情 | |
| (IX) | 40668 | dichloro(methoxy)methane; dichloromethyl methyl ether | 4885-02-3 | C2H4Cl2O | 详情 | 详情 |
| (X) | 59393 | ethyl 3-(9-formyl-5-oxo-5,6,7,13-tetrahydro-12H-indeno[2,1-a]pyrrolo[3,4-c]carbazol-12-yl)propanoate | C27H22N2O4 | 详情 | 详情 | |
| (XI) | 59394 | 12-(3-hydroxypropyl)-9-(isopropoxymethyl)-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[3,4-c]carbazol-5-one | C28H28N2O3 | 详情 | 详情 | |
| (XII) | 16765 | 2-(dimethylamino)acetic acid; N,N-Dimethylglycine | 1118-68-9 | C4H9NO2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(IX)The reaction of indoline (I) with formic acid in refluxing toluene gives N-formylindoline (II), which is treated with chlorosulfonic acid to yield 5-(chlorosulfonyl)indoline-1-carbaldehyde (III). The reaction of (III) with 3,4,5-trimethoxyaniline (IV) and pyridine in THF affords the sulfonamide (V), which is deformylated to sulfonamide (VI) with HCl in methanol. The reaction of indoline (VI) with salcomine and O2 in methanol provides the corresponding indole derivative (VII), which is methylated with methyl iodide and NaHMDS in THF to give 1-methyl-N-(3,4,5-trimethoxyphenyl)-1H-indole-5-sulfonamide (VIII). Finally, this compound is condensed with N,N-dimethylglycine (IX) by means of DCC and 4-(1-pyrrolidinyl)pyridine (pypyr) in dichloromethane.
| 【1】 Li, Q.; Woods, K.W.; Steiner, A.; et al.; Synthesis and biological evaluation of biarylsulfonamides as tubulin polymerization inhibitors. Discovery of A-318315 and A-293620 as orally and intravenously active antimitotic agents. Proc Am Assoc Cancer Res 2002, 43, Abst 1313. |
| 【2】 Barr, K.J.; Steiner, B.A.; Qun, L.; Rosenberg, S.; Sham, H.; Gwaltney, S.L. II; Imade, H.M.; Woods, K.W. (Abbott Laboratories Inc.); Cell proliferation inhibitors. WO 0073264 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19652 | indoline | 496-15-1 | C8H9N | 详情 | 详情 |
| (II) | 55546 | 1-Formylindoline | 2861-59-8 | C9H9NO | 详情 | 详情 |
| (III) | 55547 | 1-formyl-5-indolinesulfonyl chloride | C9H8ClNO3S | 详情 | 详情 | |
| (IV) | 31545 | 3,4,5-trimethoxyaniline; 3,4,5-trimethoxyphenylamine；3,4,5-Trimethoxybenzenamine；[3,4,5-Tris(methyloxy)phenyl]amine | 24313-88-0 | C9H13NO3 | 详情 | 详情 |
| (V) | 55548 | 1-formyl-N-(3,4,5-trimethoxyphenyl)-5-indolinesulfonamide | C18H20N2O6S | 详情 | 详情 | |
| (VI) | 55549 | N-(3,4,5-trimethoxyphenyl)-5-indolinesulfonamide | C17H20N2O5S | 详情 | 详情 | |
| (VII) | 55550 | N-(3,4,5-trimethoxyphenyl)-1H-indole-5-sulfonamide | C17H18N2O5S | 详情 | 详情 | |
| (VIII) | 55569 | 1-methyl-N-[3,4,5-tris(methyloxy)phenyl]-1H-indole-5-sulfonamide | C18H20N2O5S | 详情 | 详情 | |
| (IX) | 16765 | 2-(dimethylamino)acetic acid; N,N-Dimethylglycine | 1118-68-9 | C4H9NO2 | 详情 | 详情 |