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【结 构 式】

【分子编号】16481

【品名】1-(bromomethyl)-4-chlorobenzene

【CA登记号】622-95-7

【 分 子 式 】C7H6BrCl

【 分 子 量 】205.48134

【元素组成】C 40.92% H 2.94% Br 38.89% Cl 17.25%

与该中间体有关的原料药合成路线共 3 条

合成路线1

该中间体在本合成路线中的序号:(I)

Reaction of the Grignard reagent derived from 4-chlorobenzyl bromide (I) with allyl bromide (II) gives 4-(4-chlorophenyl)but-1-ene (III), which is epoxidized with peracetic acid in dichloromethane to yield 4-(4-chlorophenyl)-1,2-epoxybutane (IV). Opening of (IV) with the anion of imidazole (V) gives 1-[4-(4-chlorophenyl)-2-hydroxybutyl]imidazole (VI), which is oxidized under Swern conditions to 4-(4-chlorophenyl)-1-(1-imidazolyl)-2-butanone (VII). Ketone (VII) is then reacted with (S)-solketal tosylate [(S)-1,2-O-isopropylideneglycerol-3-O-tosylate] (VIII) in the presence of p-toluenesulfonic acid in toluene to give a mixture of stereoisomers, and (2S,4S)-cis-2-[2-(4-chlorophenyl)ethyl]-2-(imidazol-1-ylmethyl)-4-(p-toluenesulfonyloxy)methyl-1,3-dioxolane (IX) is then separated by crystallization. Finally, (IX) is treated with 4-aminothiophenol (X) in the presence of potassium carbonate in acetone.

1 Dyson, N.H.; Gardner, J.O.; Prince, A.; Kertesz, D.J. (Syntex (USA), Inc.); Process for preparing 1,3-dioxolane derivs. JP 1995508002; US 5208331 .
2 Walker, K.A.; Burton, P.M.; Swinney, D.C. (Syntex (USA), Inc.); 1,3-Dioxolane derivs. as cholesterol lowering agents. JP 1992308588; US 5158949 .
3 Walker, K.A.M.; Rotstein, D.M.; Kertesz, D.J.; et al.; Selective inhibition of mammalian lanosterol 14alpha-demethylase: A possible strategy for cholesterol lowering. J Med Chem 1993, 36, 15, 2235-7.
4 Prous, J.; Mealy, N.; Castañer, J.; RS-21607-197. Drugs Fut 1994, 19, 2, 125.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 16481 1-(bromomethyl)-4-chlorobenzene 622-95-7 C7H6BrCl 详情 详情
(II) 11463 3-Bromo-1-propene; 3-Bromopropene;allyl bromide 106-95-6 C3H5Br 详情 详情
(III) 16483 1-(3-butenyl)-4-chlorobenzene C10H11Cl 详情 详情
(IV) 16484 2-(4-chlorophenethyl)oxirane C10H11ClO 详情 详情
(V) 10255 Imidazole; 1H-Imidazole 288-32-4 C3H4N2 详情 详情
(VI) 16486 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol C13H15ClN2O 详情 详情
(VII) 16487 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone C13H13ClN2O 详情 详情
(VIII) 16488 (2S)-2,3-dihydroxypropyl 4-methylbenzenesulfonate C10H14O5S 详情 详情
(IX) 16489 [(2S,4S)-2-(4-chlorophenethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate C23H25ClN2O5S 详情 详情
(X) 16490 4-aminophenylhydrosulfide; 4-aminothiophenol; 4-aminobenzenethiol 1193-02-8 C6H7NS 详情 详情

合成路线2

该中间体在本合成路线中的序号:(II)

The title compound was obtained by the alkylation of methyl 5-(methylsulfonyl)indole-2-carboxylate (I) with 4-chlorobenzyl bromide (II) in the presence of KOH.

1 Gallo, M.A.; Trujillo, M.A.; García, L.; Cabré, F.; Pascual, J.; Mauleón, D.; Campos, J.; Espinosa, A.; Entrena, A.; Palomer, A.; Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem 2002, 45, 7, 1402.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 58559 Methyl 5-methylsulphonylindole-2-carboxylate C11H11NO4S 详情 详情
(II) 16481 1-(bromomethyl)-4-chlorobenzene 622-95-7 C7H6BrCl 详情 详情

合成路线3

该中间体在本合成路线中的序号:(VIII)

Intermediates (II) and (IV) are prepared as follows. Alkylation of the sodium enolate of methyl 3-bromophenylacetate (VII) with 4-chlorobenzyl bromide (VIII) in cold THF followed by methyl ester hydrolysis with LiOH in aqueous acetonitrile affords 2-(m-bromophenyl)-3-(p-chlorophenyl)propionic acid (IX), which is converted to the corresponding Weinreb amide (X) by chlorination with oxalyl chloride and subsequent treatment with N,O-dimethylhydroxylamine. Addition of methylmagnesium bromide to the methoxyamide (X) gives the 3,4-diaryl-2-butanone (XI), which is then reduced using NaBH4 or LiBH(s-Bu)3 (L-selectride) to provide alcohol (XIIa) as the major diastereoisomer. After conversion of alcohol (XIIa) to the corresponding mesylate, displacement with NaN3 in hot DMF leads to azide (XIII), which is reduced by catalytic hydrogenation in the presence of PtO2 and Boc2O to afford the Boc-protected amine (XIV). Then, palladium-catalyzed substitution of the aryl bromide (XIV) with zinc cyanide yields the nitrile (XV), which is deprotected to (IIa) using HCl in EtOAc (2, 3). Similarly, coupling between 3-bromobenzonitrile (XVI) and isopropenyl acetate (XVII) in the presence of Pd2(dba)3 and 2-(dicyclohexylphosphino)-2’-(dimethylamino)biphenyl (DCPDMAB) gives 1-(m-cyanophenyl)acetone (XVIII), which is alkylated with 3-chlorobenzyl chloride (XIX) in the presence of cesium hydroxide and tetrabutylammonium iodide to yield the diarylbutanone (XX). Reduction of ketone (XX) with lithium tri(sec-butyl)borohydride produces alcohol (XXI), which is converted to the Boc-protected amine (XV) by mesylation followed by displacement with NaN3, and then reduction of the resulting azide (XXII) by catalytic hydrogenation in the presence of PtO2 and Boc2O (1). The ketonitrile (XX) is alternatively produced by palladium-catalyzed cyanuration of aryl bromide (XI) with either zinc cyanide or potassium ferrocyanide. The intermediate enol tosylate (IV) can be obtained by treatment of (XX) with sodium tert-butoxide and p-toluenesulfonic anhydride (5, 6). Preparation of the enantiomerically pure amine (IIb) can be accomplished by resolution at the stage of the diarylpropionic acid (IX) or, in a more efficient method, by dynamic kinetic resolution of (XI) via stereoselective hydrogenation to (XIIb) in the presence of the chiral Ru catalyst [(S)-xyl-BINAP]-[(S)-DAIPEN]RuCl2 and excess potassium tert-butoxide (4). Scheme 2.

1 Hagmann, W.K., Lin, L.S., Shah, S.K. et al. (Merck & Co., Inc.). Substituted amides. CA 2478183, EP 1496838, JP 2005519958, JP 2006257090, US 2004058820, US 6972295, WO 03077847.
2 Hagmann, W.K., Lin, L.S., Shah, S.K. et al. (Merck & Co., Inc.). Substituted amides active at the cannabinoid-1 receptor. WO 2004048317.
3 Lin, L.S., Lanza, T.J. Jr., Jewell, J.P. et al. Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. J Med Chem 2006, 49(26): 7584-7.
4 Chen, C., Frey, L.F., Shultz, S. et al. Catalytic, enantioselective synthesis of taranabant, a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. Org Proc Res Devel 2007, 11(3): 616-23.
5 Campos, K.R., Klapars, A., McWilliams, J.C. et al. (Merck & Co., Inc.). Formation of tetra-substituted enamides and stereoselective reduction thereof. WO 2006017045.
6 Weissman, S.A. (Merck & Co., Inc.). Cyanation of aromatic halides. US 2006106223.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIIa) 65595     C16H16BrClO 详情 详情
(XIIb) 65596     C16H16BrClO 详情 详情
(Iia) 65586 3-[(1RS,2RS)-2-Amino-1-[(4-Chlorophenyl)Methyl]Propyl]Benzonitrile   C17H17ClN2 详情 详情
(Iib) 65587 3-[(1S,2S)-2-Amino-1-[(4-Chlorophenyl)Methyl]Propyl]Benzonitrile 732982-66-0 C17H17ClN2 详情 详情
(IV) 65582 (R )-(-)-4-Penten-2-ol 64584-92-5 C5H10O 详情 详情
(VII) 50901 methyl 2-(3-bromophenyl)acetate 150529-73-0 C9H9BrO2 详情 详情
(VIII) 16481 1-(bromomethyl)-4-chlorobenzene 622-95-7 C7H6BrCl 详情 详情
(IX) 65592     C15H12BrClO2 详情 详情
(X) 65593     C17H17BrClNO2 详情 详情
(XI) 65594 3-(3-Bromophenyl)-4-(4-Chlorophenyl)Butan-2-One 848310-98-5 C16H14BrClO 详情 详情
(XIII) 65597     C16H15BrClN3 详情 详情
(XIV) 65598     C21H25BrClNO2 详情 详情
(XV) 65599     C22H25ClN2O2 详情 详情
(XVI) 26573 3-bromobenzonitrile 6952-59-6 C7H4BrN 详情 详情
(XVII) 21178 isopropenyl acetate 108-22-5 C5H8O2 详情 详情
(XVIII) 65600 (3-Cyanophenyl)Acetone   C10H9NO 详情 详情
(XIX) 10356 1-Chloro-4-(chloromethyl)benzene; 4-Chlorobenzyl chloride 104-83-6 C7H6Cl2 详情 详情
(XX) 65601     C17H14ClNO 详情 详情
(XXI) 65602     C17H16ClNO 详情 详情
(XXII) 65603     C17H15ClN4 详情 详情
Extended Information