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【结 构 式】 
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【药物名称】LM-1685 【化学名称】1-(4-Chlorobenzyl)-5-(methylsulfonyl)-1H-indole-2-carboxylic acid methyl ester 【CA登记号】 【 分 子 式 】C18H16ClNO4S 【 分 子 量 】377.84952 |
【开发单位】Menarini (Originator) 【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Cyclooxygenase-2 Inhibitors |
合成路线1
The title compound was obtained by the alkylation of methyl 5-(methylsulfonyl)indole-2-carboxylate (I) with 4-chlorobenzyl bromide (II) in the presence of KOH.
| 【1】 Gallo, M.A.; Trujillo, M.A.; García, L.; Cabré, F.; Pascual, J.; Mauleón, D.; Campos, J.; Espinosa, A.; Entrena, A.; Palomer, A.; Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem 2002, 45, 7, 1402. |
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