(5S)-3-acetyl-5-methyl-2,4(3H,5H)-furandione -Drug Synthesis Database

【结构式】

【分子编号】16457

【品名】(5S)-3-acetyl-5-methyl-2,4(3H,5H)-furandione

【CA登记号】

【分子式】C₇H₈O₄

【分子量】156.13812

【元素组成】C 53.85% H 5.16% O 40.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

TRK-710 was synthesized by reaction of [1(R),2(R)-cyclohexanediamine-N,N']dihydroxoplatinum(II), (I), with 3-acetyl-5(S)-methyltetrahydrofuran-2,4-dione (II) in water.

参考文献中间体

合成目标

【1】 Hoshi, A.; Castañer, J.; TRK-710. Drugs Fut 1997, 22, 1, 38.
【2】 Hata, G.; Mutoh, M.; Hashimoto, H. (Toray Industries, Inc.); Novel platinum(II) complex and drug for treating malignant tumor. EP 0457921; JP 1991500696; US 5302587; WO 9109041 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	16456	(R,R)-Cyclohexane-1,2-diamine dihydroxy platinum complex		C₆H₁₄N₂O₂Pt	详情	详情
(II)	16457	(5S)-3-acetyl-5-methyl-2,4(3H,5H)-furandione		C₇H₈O₄	详情	详情

Extended Information