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【结 构 式】

【分子编号】16456

【品名】(R,R)-Cyclohexane-1,2-diamine dihydroxy platinum complex

【CA登记号】

【 分 子 式 】C6H14N2O2Pt

【 分 子 量 】341.26944

【元素组成】C 21.12% H 4.13% N 8.21% O 9.38% Pt 57.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

TRK-710 was synthesized by reaction of [1(R),2(R)-cyclohexanediamine-N,N']dihydroxoplatinum(II), (I), with 3-acetyl-5(S)-methyltetrahydrofuran-2,4-dione (II) in water.

1 Hoshi, A.; Castañer, J.; TRK-710. Drugs Fut 1997, 22, 1, 38.
2 Hata, G.; Mutoh, M.; Hashimoto, H. (Toray Industries, Inc.); Novel platinum(II) complex and drug for treating malignant tumor. EP 0457921; JP 1991500696; US 5302587; WO 9109041 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 16456 (R,R)-Cyclohexane-1,2-diamine dihydroxy platinum complex C6H14N2O2Pt 详情 详情
(II) 16457 (5S)-3-acetyl-5-methyl-2,4(3H,5H)-furandione C7H8O4 详情 详情
Extended Information