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【结 构 式】

【分子编号】68645

【品名】N-(6-chloro-5-methylpyridin-2-yl)pivalamide

【CA登记号】 

【 分 子 式 】C11H15ClN2O

【 分 子 量 】226.70568

【元素组成】C 58.28% H 6.67% Cl 15.64% N 12.36% O 7.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXI)

The intermediate 6-amino-2-chloro-3-methylpyridine (XIII) is prepared by protection of 2-amino-5-methylpyridine (XVIII) with pivaloyl chloride in the presence of Et3N in CH2Cl2 to give the N-pyridyl pivalamide (XIX), which is converted to the corresponding N-oxide (XX) by treatment with H2O2 in AcOH at 80 °C. Rearrangement of the N-oxide (XX) by means of POCl3 and Et3N in refluxing CH2Cl2 leads to the chloropyridine (XXI), which is finally hydrolyzed with aqueous HCl at 80 °C .

1 Hadida Rua, S., Hamilton, M., Miller, M., Grootenhuis, P.D.J., Bear, B., McCarthy, J., Zhou, J. (Vertex Pharmaceuticals, Inc.). Heterocyclic modulators of ATP-binding cassette transporters. EP 1945632, EP 2395002, EP 2404919, JP 2009514962, US 2008113985, US 7741321, US 7973038, US 2011172229, US 2011312958, US 2012232059, WO 2007056341.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 68639 6-amino-2-chloro-3-methylpyridine;2-Amino-6-chloro-5-methylpyridine;6-chloro-5-methyl-2-Pyridinamine 442129-37-5 C6H7ClN2 详情 详情
(XVIII) 12752 5-Methyl-2-pyridinylamine; 2-Amino-5-methylpyridine; 5-Methyl-2-pyridinamine; 6-Amino-beta-picoline; 6-Amino-3-picoline 1603-41-4 C6H8N2 详情 详情
(XIX) 68643 N-(5-methylpyridin-2-yl)pivalamide   C11H16N2O 详情 详情
(XX) 68644 5-methyl-2-pivalamidopyridine 1-oxide   C11H16N2O2 详情 详情
(XXI) 68645 N-(6-chloro-5-methylpyridin-2-yl)pivalamide   C11H15ClN2O 详情 详情
Extended Information