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【结 构 式】 
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【分子编号】15735 【品名】(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methanol 【CA登记号】 |
【 分 子 式 】C7H13N3O3S 【 分 子 量 】219.26464 【元素组成】C 38.34% H 5.98% N 19.16% O 21.89% S 14.62% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)1) Treatment of 4-methyl-5-hydroxymethylimidazole (I) with trimethylsilyl chloride and triethylamine followed by reaction with N,N-dimethylsulfamoyl chloride gives the protected imidazole (II). Removal of the trimethylsilyl group by means of tetrabutylammonium fluoride affords the 5-hydroxymethylimidazole (III), which is converted into the chloromethylimidazole (IV) with thionyl chloride.
| 【1】 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14216 | (5-Methyl-1H-imidazol-4-yl)methanol | 29636-87-1 | C5H8N2O | 详情 | 详情 |
| (II) | 15734 | N-methyl-N-[[(5-methyl-4-[[(trimethylsilyl)oxy]methyl]-1H-imidazol-1-yl)sulfinyl]oxy]methanamine; N,N-dimethyl-N-[[(5-methyl-4-[[(trimethylsilyl)oxy]methyl]-1H-imidazol-1-yl)sulfinyl]oxy]amine | C10H21N3O3SSi | 详情 | 详情 | |
| (III) | 15735 | (1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methanol | C7H13N3O3S | 详情 | 详情 | |
| (IV) | 15736 | N-([[4-(chloromethyl)-5-methyl-1H-imidazol-1-yl]sulfinyl]oxy)-N-methylmethanamine; N-([[4-(chloromethyl)-5-methyl-1H-imidazol-1-yl]sulfinyl]oxy)-N,N-dimethylamine | C7H12ClN3O2S | 详情 | 详情 |
Extended Information