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【结 构 式】

【分子编号】15734

【品名】N-methyl-N-[[(5-methyl-4-[[(trimethylsilyl)oxy]methyl]-1H-imidazol-1-yl)sulfinyl]oxy]methanamine; N,N-dimethyl-N-[[(5-methyl-4-[[(trimethylsilyl)oxy]methyl]-1H-imidazol-1-yl)sulfinyl]oxy]amine

【CA登记号】

【 分 子 式 】C10H21N3O3SSi

【 分 子 量 】291.44666

【元素组成】C 41.21% H 7.26% N 14.42% O 16.47% S 11% Si 9.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

1) Treatment of 4-methyl-5-hydroxymethylimidazole (I) with trimethylsilyl chloride and triethylamine followed by reaction with N,N-dimethylsulfamoyl chloride gives the protected imidazole (II). Removal of the trimethylsilyl group by means of tetrabutylammonium fluoride affords the 5-hydroxymethylimidazole (III), which is converted into the chloromethylimidazole (IV) with thionyl chloride.

1 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 14216 (5-Methyl-1H-imidazol-4-yl)methanol 29636-87-1 C5H8N2O 详情 详情
(II) 15734 N-methyl-N-[[(5-methyl-4-[[(trimethylsilyl)oxy]methyl]-1H-imidazol-1-yl)sulfinyl]oxy]methanamine; N,N-dimethyl-N-[[(5-methyl-4-[[(trimethylsilyl)oxy]methyl]-1H-imidazol-1-yl)sulfinyl]oxy]amine C10H21N3O3SSi 详情 详情
(III) 15735 (1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methanol C7H13N3O3S 详情 详情
(IV) 15736 N-([[4-(chloromethyl)-5-methyl-1H-imidazol-1-yl]sulfinyl]oxy)-N-methylmethanamine; N-([[4-(chloromethyl)-5-methyl-1H-imidazol-1-yl]sulfinyl]oxy)-N,N-dimethylamine C7H12ClN3O2S 详情 详情
Extended Information