(4S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione -Drug Synthesis Database

【结构式】

【分子编号】15634

【品名】(4S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

【CA登记号】

【分子式】C₂₀H₁₅N₃O₆

【分子量】393.35572

【元素组成】C 61.07% H 3.84% N 10.68% O 24.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

9-Amino-20(S)-camptothecin is obtained by nitration of camptothecin (I) with fuming nitric acid in concentrated sulfuric acid yielding the intermediate 9-nitrocamptothecin (II), which is then reduced with H2 over PtO2 in absolute ethanol.

参考文献中间体

合成目标

【1】 Robinson, C.; Robinson, K.; Castaner, J.; 9-Aminocamptothecin. Drugs Fut 1996, 21, 9, 881.
【2】 Wani, M.C.; Nicholas, A.W.; Wall, M.E.; Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. J Med Chem 1986, 29, 11, 2358.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10816	Camptothecin; (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 4-et-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo(b,h)fluorene-3,13-dione	7689-03-4	C₂₀H₁₆N₂O₄	详情	详情
(II)	15634	(4S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione		C₂₀H₁₅N₃O₆	详情	详情

Extended Information