4-chloro-N-[3,5-di(tert-butyl)-4-hydroxyphenyl]butanamide -Drug Synthesis Database

【结构式】

【分子编号】15604

【品名】4-chloro-N-[3,5-di(tert-butyl)-4-hydroxyphenyl]butanamide

【CA登记号】

【分子式】C₁₈H₂₈ClNO₂

【分子量】325.87856

【元素组成】C 66.34% H 8.66% Cl 10.88% N 4.3% O 9.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The 2,6-di-tert-butylphenol (I) was nitrated with nitric acid, followed by reduction with hydrogen using a platinum catalyst to afford 4-amino-2,6-di-tert-butylphenol (II). The reaction of (II) with 4-chlorobutyryl chloride (III) gave the intermediate 4-chlorobutyramide (IV), which on treatment with sodium hydride underwent cyclization to afford 1-(3,5-di-tert-butyl-4-hydroxyphenyl)pyrrolidin-2-one, BF-388.

参考文献中间体

合成目标

【1】 Naismith, R.W.; Frierson, M.R. III, Wong, S.; Lee, S.J.; BF-388. Drugs Fut 1992, 17, 10, 871.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25925	2,6-di(tert-butyl)phenol	128-39-2	C₁₄H₂₂O	详情	详情
(II)	15603	4-amino-2,6-di(tert-butyl)phenol		C₁₄H₂₃NO	详情	详情
(III)	11265	4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride	4635-59-0	C₄H₆Cl₂O	详情	详情
(IV)	15604	4-chloro-N-[3,5-di(tert-butyl)-4-hydroxyphenyl]butanamide		C₁₈H₂₈ClNO₂	详情	详情

Extended Information