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【结 构 式】 
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【药物名称】BF-388 【化学名称】1-(3,5-Di-tert-butyl-4-hydroxyphenyl)pyrrolidin-2-one 【CA登记号】129464-78-4 【 分 子 式 】C18H27NO2 【 分 子 量 】289.42139 |
【开发单位】Biofor (Originator) 【药理作用】Non-Steroidal Antiinflammatory Drugs |
合成路线1
The 2,6-di-tert-butylphenol (I) was nitrated with nitric acid, followed by reduction with hydrogen using a platinum catalyst to afford 4-amino-2,6-di-tert-butylphenol (II). The reaction of (II) with 4-chlorobutyryl chloride (III) gave the intermediate 4-chlorobutyramide (IV), which on treatment with sodium hydride underwent cyclization to afford 1-(3,5-di-tert-butyl-4-hydroxyphenyl)pyrrolidin-2-one, BF-388.
| 【1】 Naismith, R.W.; Frierson, M.R. III, Wong, S.; Lee, S.J.; BF-388. Drugs Fut 1992, 17, 10, 871. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25925 | 2,6-di(tert-butyl)phenol | 128-39-2 | C14H22O | 详情 | 详情 |
| (II) | 15603 | 4-amino-2,6-di(tert-butyl)phenol | C14H23NO | 详情 | 详情 | |
| (III) | 11265 | 4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride | 4635-59-0 | C4H6Cl2O | 详情 | 详情 |
| (IV) | 15604 | 4-chloro-N-[3,5-di(tert-butyl)-4-hydroxyphenyl]butanamide | C18H28ClNO2 | 详情 | 详情 |
Extended Information