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【结 构 式】 
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【分子编号】14463 【品名】ethyl 2-(3,4-dihydro-2H-chromen-4-yl)acetate 【CA登记号】 |
【 分 子 式 】C13H16O3 【 分 子 量 】220.26824 【元素组成】C 70.89% H 7.32% O 21.79% |
合成路线1
该中间体在本合成路线中的序号：(III)The racemic compound RP 58866 was synthesized as follows: The ethyl ester of (2,3-dihydro-4H-1-benzopyran-4-ylidene)acetic acid (II) is prepared by carrying out the Wittig-Horner reaction on commercially available chromanone (I), followed by catalytic hydrogenation over 10% Pd on carbon to yield the ethyl ester of 3,4-dihydro-2H-1-benzopyran-4-acetic acid (III). Reduction of this ester with lithium aluminum hydride gives the alcohol (IV), which is converted into the corresponding bromide (V) (1, 3) by reaction with N,N'-carbonyldiimidazole and an excess of allyl bromide. Subsequent condensation of (V) with 4-(3,4-dimethoxyphenyl)piperidine (VI) by refluxing in 2-butanone, followed by the addition of (E)-2-butenedioic acid (fumaric acid), yields the salt (RS)-1-[2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperidine (E)-2-butenedioate (1:1) (VII).
| 【1】 Hardy, J.-C.; Renault, C. (Aventis SA); Novel benzopyran derivs., their preparation and medicines containing them. (Rhône-Poulenc Santé). AU 8819713; EP 0300908; FR 2618437; JP 1989040476; US 4977166 . |
| 【2】 Barreau, M.; Hardy, J.-C.; Martin, J.-P.; Renault, C. (Aventis SA); Benzopyran derivs., their preparation and pharmaceutical compsns. Containing them. (Rhône-Poulenc Santé). AU 9048584; EP 0379441; FR 2642069; JP 1990233675; US 5025013 . |
| 【3】 Barreau, M.; Hardy, J.-C.; Renault, C. (Aventis SA); Novel benzopyran derivs., their preparation and pharmaceutical compsns. containing them. (Rhône-Poulenc Santé). AU 9048583; EP 0379440; FR 2642068; JP 1990229188; US 4994470 . |
| 【4】 Mestre, M.; Cavero, I.; Hardy, J.-C.; Barreau, M.; Terikalant Fumarate. Drugs Fut 1992, 17, 12, 1097. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10019 | Ethyl 2-(diethoxyphosphoryl)acetate; Triethyl phosphonoacetate | 867-13-0 | C8H17O5P | 详情 | 详情 | |
| 23808 | Fumaric acid; (E)-2-butenedioic acid | 110-17-8 | C4H4O4 | 详情 | 详情 | |
| (I) | 14461 | 2,3-Dihydro-4H-chromen-4-one; 4-Chromanone | 491-37-2 | C9H8O2 | 详情 | 详情 |
| (II) | 14462 | ethyl 2-(2,3-dihydro-4H-chromen-4-ylidene)acetate | C13H14O3 | 详情 | 详情 | |
| (III) | 14463 | ethyl 2-(3,4-dihydro-2H-chromen-4-yl)acetate | C13H16O3 | 详情 | 详情 | |
| (IV) | 14464 | 2-(3,4-dihydro-2H-chromen-4-yl)-1-ethanol | C11H14O2 | 详情 | 详情 | |
| (V) | 14465 | 4-(2-bromoethyl)chromane | C11H13BrO | 详情 | 详情 | |
| (VI) | 14466 | 4-(3,4-dimethoxyphenyl)piperidine; 2-methoxy-4-(4-piperidinyl)phenyl methyl ether | C13H19NO2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(III)Terikalant, the (S)-enantiomer of RP 58866, was synthesized as follows: After hydrolysis of the ethyl ester (III) with NaOH in refluxing methanol, the corresponding acid (VIII) is converted into the acid chloride by refluxing in thionyl chloride. After removal of excess thionyl chloride, the residue is distilled off under reduced pressure to yield the carboxylic acid chloride (IX). Subsequent reaction of (IX) with (R)-(-)-phenylglycinol yields a mixture of the (SR)-3,4-dihydro-N-(2-hydroxy-1-phenethyl)-2H-1-benzopyran-4-acetamide (Xa) [m.p. 143 C; alpha(D) -43 (c 1.5, EtOH)] and (RR)-3,4-dihydro-N-(2-hydroxy-1-phenethyl)-2H-1-benzopyran-4-acetamide (Xb) [m.p. 140 C; alpha(D) -6.5 (c 1.5, EtOH)] diastereoisomers, which are separated by silica gel column chromatography using methylene chloride/ethanol (95/5) as eluent and subsequently hydrolyzed to give the two pure enatiomeric carboxylic acids: (S)-(XIa) [alpha(D) -18.5 (c 1.1, EtOH)], e.e. 99.3% determined by analytical HPLC on the amide derived from (R)-(-)-phenylglycinol, and (R)-(XIb) [alpha(D) +17.4 (c 1, EtOH)]; m.p. 77-8 C. Reduction of (XIa) with lithium aluminum hydride in tetrahydrofuran gives the alcohol (XII), which is converted into the bromide (XIII) and, subsequently, to (S)-1-[2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)piperidine (E)-2-butenedioate (1:1) , analogously with the racemic compound described in scheme 16777901a. RP 62719 is recrystallized from isopropanol and the absolute configuration is obtained through single crystal x-ray analysis of the bromhydrate. The pure (R)-isomer, RP 62718, is obtained according to the same reaction scheme as that described for (XIa), but starting with (XIb).
| 【1】 Cavero, I.; Renault, C.; Hardy, J.-C.; Barreau, M.; Bouquerel, J.; Mestre, M.; Synthesis and biological evaluation of RP 62719, the active enantiomer of RP 58866, a pure class III antiarrhythmic agent. 11th Int Symp Med Chem (Sept 2-7, Jerusalem) 1990, 37. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 14376 | (2R)-2-amino-2-phenyl-1-ethanol; (R)-(-)-2-phenylglycinol; (R)-2-amino-2-phenyl-1-ethanol | 56613-80-0 | C8H11NO | 详情 | 详情 | |
| 23808 | Fumaric acid; (E)-2-butenedioic acid | 110-17-8 | C4H4O4 | 详情 | 详情 | |
| (Xb) | 14469 | 2-[(4S)-3,4-dihydro-2H-chromen-4-yl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide | C19H21NO3 | 详情 | 详情 | |
| (Xa) | 14470 | 2-[(4R)-3,4-dihydro-2H-chromen-4-yl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide | C19H21NO3 | 详情 | 详情 | |
| (XIb) | 14471 | 2-[(4S)-3,4-dihydro-2H-chromen-4-yl]acetic acid | C11H12O3 | 详情 | 详情 | |
| (XIa) | 14472 | 2-[(4R)-3,4-dihydro-2H-chromen-4-yl]acetic acid | C11H12O3 | 详情 | 详情 | |
| (III) | 14463 | ethyl 2-(3,4-dihydro-2H-chromen-4-yl)acetate | C13H16O3 | 详情 | 详情 | |
| (VI) | 14466 | 4-(3,4-dimethoxyphenyl)piperidine; 2-methoxy-4-(4-piperidinyl)phenyl methyl ether | C13H19NO2 | 详情 | 详情 | |
| (VIII) | 14467 | 2-(3,4-dihydro-2H-chromen-4-yl)acetic acid | C11H12O3 | 详情 | 详情 | |
| (IX) | 14468 | 2-(3,4-dihydro-2H-chromen-4-yl)acetyl chloride | C11H11ClO2 | 详情 | 详情 | |
| (XII) | 14473 | 2-[(4S)-3,4-dihydro-2H-chromen-4-yl]-1-ethanol | C11H14O2 | 详情 | 详情 | |
| (XIII) | 14474 | (4R)-4-(2-bromoethyl)-3,4-dihydro-2H-chromene | C11H13BrO | 详情 | 详情 |