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【结 构 式】

【分子编号】14210

【品名】3-(4-Fluorophenyl)-3-oxopropanenitrile

【CA登记号】

【 分 子 式 】C9H6FNO

【 分 子 量 】163.1511832

【元素组成】C 66.26% H 3.71% F 11.64% N 8.59% O 9.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The condensation of cyclooctanone (I) with 4-fluorobenzoylacetonitrile (II) by heating with polyphosphoric acid at 120 C gives 4-fluorophenyl-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2(1H)-one (III), which is converted to the corresponding 2-chloro derivative (IV) by treatment with refluxing phosphoryl chloride. The reaction of (IV) with 1-ethylpiperazine (V) at 170 C affords AD-5423.

1 Hino, K.; Kai, N.; Sakamoto, M.; Kon, T.; Oka, M.; Furakawa, K.; Ochi, Y. (Dainippon Pharmaceutical Co., Ltd.); 2-(1-Piperazinyl)-4-phenylcycloalkanopyridine derivs., processes for the production thereof, and pharmaceutical compsn. containing the same. EP 0385237; JP 1991007257; JP 1994041079; US 5021421 .
2 Oka, M.; Hino, K.; AD-5423. Drugs Fut 1992, 17, 1, 9.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 14209 Cyclooctanone 502-49-8 C8H14O 详情 详情
(II) 14210 3-(4-Fluorophenyl)-3-oxopropanenitrile C9H6FNO 详情 详情
(III) 14211 4-(4-Fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2(1H)-one C17H18FNO 详情 详情
(IV) 14212 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine C17H17ClFN 详情 详情
(V) 14213 N-Ethylpiperazine; 1-Ethylpiperazine 5308-25-8 C6H14N2 详情 详情
Extended Information