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【结 构 式】 
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【分子编号】14209 【品名】Cyclooctanone 【CA登记号】502-49-8 |
【 分 子 式 】C8H14O 【 分 子 量 】126.19856 【元素组成】C 76.14% H 11.18% O 12.68% |
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of cyclooctanone (I) with 4-fluorobenzoylacetonitrile (II) by heating with polyphosphoric acid at 120 C gives 4-fluorophenyl-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2(1H)-one (III), which is converted to the corresponding 2-chloro derivative (IV) by treatment with refluxing phosphoryl chloride. The reaction of (IV) with 1-ethylpiperazine (V) at 170 C affords AD-5423.
| 【1】 Hino, K.; Kai, N.; Sakamoto, M.; Kon, T.; Oka, M.; Furakawa, K.; Ochi, Y. (Dainippon Pharmaceutical Co., Ltd.); 2-(1-Piperazinyl)-4-phenylcycloalkanopyridine derivs., processes for the production thereof, and pharmaceutical compsn. containing the same. EP 0385237; JP 1991007257; JP 1994041079; US 5021421 . |
| 【2】 Oka, M.; Hino, K.; AD-5423. Drugs Fut 1992, 17, 1, 9. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14209 | Cyclooctanone | 502-49-8 | C8H14O | 详情 | 详情 |
| (II) | 14210 | 3-(4-Fluorophenyl)-3-oxopropanenitrile | C9H6FNO | 详情 | 详情 | |
| (III) | 14211 | 4-(4-Fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2(1H)-one | C17H18FNO | 详情 | 详情 | |
| (IV) | 14212 | 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine | C17H17ClFN | 详情 | 详情 | |
| (V) | 14213 | N-Ethylpiperazine; 1-Ethylpiperazine | 5308-25-8 | C6H14N2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XI)The chloroformylation of cyclooctanone (XI) with DMF and POCl3 gives 2-chloro-1-cyclooctenecarbaldehyde (XII), which is dechlorinated and hydrogenated with H2 over Pd/C to afford the desired intermediate (II).
| 【1】 Kawamoto, H.; et al.; Synthesis of J-113397, the first potent and selective ORL1 antagonist. Tetrahedron 2001, 57, 6, 981. |
合成路线3
该中间体在本合成路线中的序号：(I)Cyclooctanone tosylhydrazone was treated with n-BuLi and subsequently reacted with DMF to afford (II). Compound (III) was prepared from 4-tert-butoxycarbonylpiperidine by reductive alkylation with (II). Deprotection of (III) and condensation with 2,7-dichloroxanthen-9-carboxylic acid (IV) using 1,1'-carbonyldiimidazole (CDI) afforded (V). Compound (V) was quaternarized with iodoethane to provide a quaternary ammonium derivative as a mixture of two isomers (cis and trans) attributed to the 4-substituted piperidinium structure in a ratio of 2:1. Finally, the mixture was separated by silica gel column chromatography to give a major isomer, J-113863.
| 【1】 Naya, A.; et al.; Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem 2001, 44, 9, 1429. |
| 【2】 Saeki, T.; Naya, A.; J-113863. Drugs Fut 2001, 26, 2, 121. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14209 | Cyclooctanone | 502-49-8 | C8H14O | 详情 | 详情 |
| (II) | 37975 | 1-cyclooctene-1-carbaldehyde | C9H14O | 详情 | 详情 | |
| (III) | 41601 | tert-butyl 4-piperidinylcarbamate; 4-tert-Boc-aminopiperidine | 73874-95-0 | C10H20N2O2 | 详情 | 详情 |
| (IV) | 44356 | tert-butyl 1-(1-cycloocten-1-ylmethyl)-4-piperidinylcarbamate | C19H34N2O2 | 详情 | 详情 | |
| (V) | 37972 | 2,7-dichloro-9H-xanthene-9-carboxylic acid | C14H8Cl2O3 | 详情 | 详情 | |
| (VI) | 37976 | 2,7-dichloro-N-[1-(1-cycloocten-1-ylmethyl)-4-piperidinyl]-9H-xanthene-9-carboxamide | C28H32Cl2N2O2 | 详情 | 详情 |