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【结 构 式】 
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【分子编号】13644 【品名】(2-Fluorophenyl)(4-fluorophenyl)phenylmethanol 【CA登记号】 |
【 分 子 式 】C19H14F2O 【 分 子 量 】296.3163664 【元素组成】C 77.02% H 4.76% F 12.82% O 5.4% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)A new synthesis for flutrimazole has been reported: The Grignard condensation of 2-fluorobenzophenone (I) with 4-fluorophenylmagnesium bromide (II) gives the corresponding triphenylcarbinol (III), which by reaction with refluxing SOCl2 is converted to the trityl chloride (IV). Finally, this compound is condensed with imidazole (V) in acetonitrile.
| 【1】 Forn, J.; Bartrolí, J.; Algueró, M.; Boncompte, E.; Synthesis and antifungal activity of a series of difluorotritylimidazoles. Arzneim-Forsch Drug Res 1992, 42, 6, 832. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13642 | (2-Fluorophenyl)(phenyl)methanone; 2-Fluorobenzophenone | 342-24-5 | C13H9FO | 详情 | 详情 |
| (II) | 13643 | 4-fluorophenyl magnesium bromide;Bromo(4-fluorophenyl)magnesium;bromo(p-fluorophenyl)Magnesium;p-Fluorophenylmagnesium bromide | 352-13-6 | C6H4BrFMg | 详情 | 详情 |
| (III) | 13644 | (2-Fluorophenyl)(4-fluorophenyl)phenylmethanol | C19H14F2O | 详情 | 详情 | |
| (IV) | 13645 | 1-[Chloro(4-fluorophenyl)benzyl]-2-fluorobenzene | C19H13ClF2 | 详情 | 详情 | |
| (V) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
Extended Information