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【结 构 式】 
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【药物名称】Flutrimazole, UR-4056, Flusporan, Cutiman, Micetal 【化学名称】1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole 【CA登记号】119006-77-8 【 分 子 式 】C22H16F2N2 【 分 子 量 】346.38302 |
【开发单位】Uriach (Originator), Biohorm (Licensee), Menarini (Licensee) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY |
合成路线1
A new synthesis for flutrimazole has been reported: The Grignard condensation of 2-fluorobenzophenone (I) with 4-fluorophenylmagnesium bromide (II) gives the corresponding triphenylcarbinol (III), which by reaction with refluxing SOCl2 is converted to the trityl chloride (IV). Finally, this compound is condensed with imidazole (V) in acetonitrile.
| 【1】 Forn, J.; Bartrolí, J.; Algueró, M.; Boncompte, E.; Synthesis and antifungal activity of a series of difluorotritylimidazoles. Arzneim-Forsch Drug Res 1992, 42, 6, 832. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13642 | (2-Fluorophenyl)(phenyl)methanone; 2-Fluorobenzophenone | 342-24-5 | C13H9FO | 详情 | 详情 |
| (II) | 13643 | 4-fluorophenyl magnesium bromide;Bromo(4-fluorophenyl)magnesium;bromo(p-fluorophenyl)Magnesium;p-Fluorophenylmagnesium bromide | 352-13-6 | C6H4BrFMg | 详情 | 详情 |
| (III) | 13644 | (2-Fluorophenyl)(4-fluorophenyl)phenylmethanol | C19H14F2O | 详情 | 详情 | |
| (IV) | 13645 | 1-[Chloro(4-fluorophenyl)benzyl]-2-fluorobenzene | C19H13ClF2 | 详情 | 详情 | |
| (V) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
Extended Information