Benzoic acid,4-[1-hydroxy-1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethyl]- -Drug Synthesis Database

【结构式】

【分子编号】66155

【品名】Benzoic acid,4-[1-hydroxy-1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethyl]-

【CA登记号】852524-20-0

【分子式】C₂₄H₃₀O₃

【分子量】366.5004

【元素组成】C 78.65% H 8.25% O 13.1%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

【1】 Faul, M.M.; Ratz, A.M.; Sullivan, K.A.; Trankle, W.G.; Winneroski, L.L.; Synthesis of novel retinoid X receptor-selective retinoids. J Org Chem 2001, 66, 17, 5772.
【1】 WeiL．Yang H，ZhuQIn. 2003．Preparation of bexarotene antitunnr agent发明专利申请公开说明书，CN 1429807

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	35219	4-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)carbonyl]benzoic acid		C₂₃H₂₆O₃	详情	详情
(I)	35217	1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene		C₁₅H₂₂	详情	详情
(II)	66155	Benzoic acid,4-[1-hydroxy-1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethyl]-	852524-20-0	C₂₄H₃₀O₃	详情	详情
(II)	60252	6-bromo-1,1,4,4,7-pentamethyl-1,2,3,4-tetrahydronaphthalene		C₁₅H₂₁Br	详情	详情
(III)	60253	3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenylboronic acid		C₁₅H₂₃BO₂	详情	详情
(IV)	60255	methyl 4-acetylbenzoate		C₁₀H₁₀O₃	详情	详情
(V)	60254	methyl 4-(1-{[(trifluoromethyl)sulfonyl]oxy}ethenyl)benzoate		C₁₁H₉F₃O₅S	详情	详情
(VI)	60246	methyl 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)ethenyl]benzoate		C₂₅H₃₀O₂	详情	详情

Extended Information