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【结 构 式】 
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【分子编号】12965 【品名】1-[(Chlorocarbonyl)(methyl)amino]ethane 【CA登记号】42252-34-6 |
【 分 子 式 】C4H8ClNO 【 分 子 量 】121.56636 【元素组成】C 39.52% H 6.63% Cl 29.16% N 11.52% O 13.16% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)Reaction of 3-[1-(dimethylamino)ethyl]phenol (I) with N-ethyl-N-methylcarbamoyl chloride (II) and sodium hydride in tetrahydrofuran gives racemic N-ethyl-N-methylcarbamic acid 3-[1-(dimethylamino)ethyl]phenyl ester (III), which is resolved by recrystallization with (+)-D-di-O,O'-(p-toluoyl)tartaric acid in methanol followed by treatment with base.
| 【1】 Enz, A. (Novartis Deutschland GmbH); Phenylcarbamate. AU 8812554; BE 1001467; CH 675720; DE 3805744; FR 2611707; GB 2203040; JP 1988238054; JP 1997118617; JP 1997165362 . |
| 【2】 Amstutz, R.; Walkinshaw, M.; Marzi, M.; Enz, A.; Boelsterli, J.; Cyclic phenyl-carbamates of the myotin-type and their action on acetylcholinesterase. Helv Chim Acta 1990, 73, 739-53. |
| 【3】 Rabasseda, X.; Castaner, J.; Prous, J.; SDZ-ENA-713. Drugs Fut 1994, 19, 7, 656. |
合成路线2
该中间体在本合成路线中的序号：(II)
| 【1】 Fieldhouse R 2005. Stereoselective process for the preparation of tertiary amines attached to a secondary carbon center using a chiral transition metal transfer hydrogenation catalyst. W0 2005058804(本专利属于Avecia Pharmaceuticals Limited, UK) |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40588 | N-methyl-1-ethanamine; N-ethyl-N-methylamine | 624-78-2 | C3H9N | 详情 | 详情 |
| (II) | 12965 | 1-[(Chlorocarbonyl)(methyl)amino]ethane | 42252-34-6 | C4H8ClNO | 详情 | 详情 |
| (III) | 66638 | 3-acetylphenyl ethyl(methyl)carbamate | C12H15NO3 | 详情 | 详情 | |
| (IV) | 66640 | (R）-3-(amino(hydroxy)methyl)phenyl ethyl(methyl)carbamate | C11H16N2O3 | 详情 | 详情 |
Extended Information