【结 构 式】 |
【分子编号】12557 【品名】methyl 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate 【CA登记号】 |
【 分 子 式 】C14H21N5O4 【 分 子 量 】323.35204 【元素组成】C 52% H 6.55% N 21.66% O 19.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The cyclization of 1-butyl-6-chloro-5-cyano-3-propyluracil (I) with methoxycarbonylhydrazine (II) in refluxing methanol yields 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylic acid ethyl ester (III), which is then methylated with methyl iodide and K2CO3 in DMF.
【1】 Furukawa, Y.; Maki, Y. (Takeda Chemical Industries, Ltd.); 3-Aminopyrazolo(3,4-d)pyrimidine derivs. and production thereof. EP 0166054 . |
【2】 Prous, J.; Castaner, J.; AA-2379. Drugs Fut 1990, 15, 5, 443. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 12555 | 1-Butyl-6-chloro-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile | C12H16ClN3O2 | 详情 | 详情 | |
(II) | 12556 | methyl 1-hydrazinecarboxylate; methyl carbazate | 6294-89-9 | C2H6N2O2 | 详情 | 详情 |
(III) | 12557 | methyl 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate | C14H21N5O4 | 详情 | 详情 |
Extended Information