【结 构 式】 |
【药物名称】AA-2379 【化学名称】7-Butyl-3-(methylamino)-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylic acid methyl ester 【CA登记号】103446-98-6 【 分 子 式 】C15H23N5O4 【 分 子 量 】337.38166 |
【开发单位】Takeda (Originator) 【药理作用】Non-Steroidal Antiinflammatory Drugs |
合成路线1
The cyclization of 1-butyl-6-chloro-5-cyano-3-propyluracil (I) with methoxycarbonylhydrazine (II) in refluxing methanol yields 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylic acid ethyl ester (III), which is then methylated with methyl iodide and K2CO3 in DMF.
【1】 Furukawa, Y.; Maki, Y. (Takeda Chemical Industries, Ltd.); 3-Aminopyrazolo(3,4-d)pyrimidine derivs. and production thereof. EP 0166054 . |
【2】 Prous, J.; Castaner, J.; AA-2379. Drugs Fut 1990, 15, 5, 443. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 12555 | 1-Butyl-6-chloro-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile | C12H16ClN3O2 | 详情 | 详情 | |
(II) | 12556 | methyl 1-hydrazinecarboxylate; methyl carbazate | 6294-89-9 | C2H6N2O2 | 详情 | 详情 |
(III) | 12557 | methyl 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate | C14H21N5O4 | 详情 | 详情 |
Extended Information