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【结 构 式】

【分子编号】12077

【品名】4-Chloro-1-[4-(1,1-dimethylethyl)phenyl]-1-butanone; 1-[4-(tert-Butyl)phenyl]-4-chloro-1-butanone; 4'-tert-Butyl-4-chlorobutyrophenone

【CA登记号】43076-61-5

【 分 子 式 】C14H19ClO

【 分 子 量 】238.75696

【元素组成】C 70.43% H 8.02% Cl 14.85% O 6.7%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(III)

1) By condensation of 4-methoxybenzylamine (I) with N,N',S-trimethylisothiourea hydroiodide (C) in refluxing ethanol, followed by treatment with H2SO4.

1 Thorpe, P.; Castaner, J.; Terfenadine. Drugs Fut 1978, 3, 3, 220.
2 Carr, A.A.; Kinsolving, C.R. (Aventis Pharmaceuticals, Inc.); 1-Aroylalkyl-4-diphenylmethyl piperidines. DE 2303305; ES 410730; FR 2181692; GB 1412605; JP 48085576; US 3806526 .
3 Carr, A.A.; Kinsolving, C.R. (Aventis Pharmaceuticals, Inc.); Olefinic 4-substituted piperidino deriatives. ES 410732; FR 2181689; GB 1413140; JP 48085579; US 3862173 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17179 2-[4-(4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butanoyl)phenyl]-2-methylpropyl acetate 76811-96-6 C34H41NO4 详情 详情
(III) 12077 4-Chloro-1-[4-(1,1-dimethylethyl)phenyl]-1-butanone; 1-[4-(tert-Butyl)phenyl]-4-chloro-1-butanone; 4'-tert-Butyl-4-chlorobutyrophenone 43076-61-5 C14H19ClO 详情 详情
(IV) 39797 1-[4-(tert-butyl)phenyl]-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-1-butanone C32H39NO2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(II)

This compound can be obtained by two related routes: 1) Condensation of 4-hydroxypiperidine (I) with p-tert-butyl-omega-chlorobutyrophenone (II) in hot methyl isobutyl ketone in presence of sodium bicarbonate gives 1-[3-(4-tert-butylbenzoyl)propyl]-4-hydroxypiperidine (III), which reacts with diphenylmethyl bromide (IV) in methyl isobutyl ketone to give ebastine. 2) 4-Diphenylmethoxypiperidine (VI), obtained by alkaline hydrolysis of 1-ethoxycarbonyl-4-diphenyl-methoxypiperidine (V) was reacted with p-tert-butyl-omega-chlorobutyrophenone (II) to give ebastine.

1 Spickett, R.G.W.; Moragues, J.; Prieto, J.; Vega, A. (Fordonal S.A.); Piperidine derivs. EP 0134124B; US 4550116 .
2 Moragues, J.; Roberts, D.J.; EBASTINE. Drugs Fut 1990, 15, 7, 674.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12076 4-Piperidinol; 4-Hydroxypiperidine 5382-16-1 C5H11NO 详情 详情
(II) 12077 4-Chloro-1-[4-(1,1-dimethylethyl)phenyl]-1-butanone; 1-[4-(tert-Butyl)phenyl]-4-chloro-1-butanone; 4'-tert-Butyl-4-chlorobutyrophenone 43076-61-5 C14H19ClO 详情 详情
(III) 12078 1-[4-(tert-Butyl)phenyl]-4-(4-hydroxypiperidino)-1-butanone C19H29NO2 详情 详情
(IV) 12079 Bromodiphenylmethane; 1-[Bromo(phenyl)methyl]benzene; Benzhydrylbromide 776-74-9 C13H11Br 详情 详情
(V) 12080 ethyl 4-(benzhydryloxy)tetrahydro-1(2H)-pyridinecarboxylate C21H25NO3 详情 详情
(VI) 12081 4-(Benzhydryloxy)piperidine; Benzhydryl 4-piperidinyl ether C18H21NO 详情 详情
Extended Information