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【结 构 式】 
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【药物名称】Ebastine, RP-64305, LAS-W-090, W-090, Evastel, No-Sedat, Kestine, Bastel, Ebastel 【化学名称】4'-tert-Butyl-4-[4-(diphenylmethoxy)piperidin-1-yl]butyrophenone 【CA登记号】90729-43-4 【 分 子 式 】C32H39NO2 【 分 子 量 】469.67313 |
【开发单位】Almirall Prodesfarma (Originator), Boryung (Licensee), Dainippon Pharmaceutical (Licensee), High Noon Labs. (Licensee), Meiji Seika (Licensee), Nycomed Pharma (Licensee) 【药理作用】Allergic Skin Disorders, Treatment for, Antiallergy/Antiasthmatic Drugs, Asthma Therapy, DERMATOLOGIC DRUGS, Drugs for Allergic Rhinitis, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Urticaria, Treatment for, Histamine H1 Antagonists |
合成路线1
This compound can be obtained by two related routes: 1) Condensation of 4-hydroxypiperidine (I) with p-tert-butyl-omega-chlorobutyrophenone (II) in hot methyl isobutyl ketone in presence of sodium bicarbonate gives 1-[3-(4-tert-butylbenzoyl)propyl]-4-hydroxypiperidine (III), which reacts with diphenylmethyl bromide (IV) in methyl isobutyl ketone to give ebastine. 2) 4-Diphenylmethoxypiperidine (VI), obtained by alkaline hydrolysis of 1-ethoxycarbonyl-4-diphenyl-methoxypiperidine (V) was reacted with p-tert-butyl-omega-chlorobutyrophenone (II) to give ebastine.
| 【1】 Spickett, R.G.W.; Moragues, J.; Prieto, J.; Vega, A. (Fordonal S.A.); Piperidine derivs. EP 0134124B; US 4550116 . |
| 【2】 Moragues, J.; Roberts, D.J.; EBASTINE. Drugs Fut 1990, 15, 7, 674. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
| (II) | 12077 | 4-Chloro-1-[4-(1,1-dimethylethyl)phenyl]-1-butanone; 1-[4-(tert-Butyl)phenyl]-4-chloro-1-butanone; 4'-tert-Butyl-4-chlorobutyrophenone | 43076-61-5 | C14H19ClO | 详情 | 详情 |
| (III) | 12078 | 1-[4-(tert-Butyl)phenyl]-4-(4-hydroxypiperidino)-1-butanone | C19H29NO2 | 详情 | 详情 | |
| (IV) | 12079 | Bromodiphenylmethane; 1-[Bromo(phenyl)methyl]benzene; Benzhydrylbromide | 776-74-9 | C13H11Br | 详情 | 详情 |
| (V) | 12080 | ethyl 4-(benzhydryloxy)tetrahydro-1(2H)-pyridinecarboxylate | C21H25NO3 | 详情 | 详情 | |
| (VI) | 12081 | 4-(Benzhydryloxy)piperidine; Benzhydryl 4-piperidinyl ether | C18H21NO | 详情 | 详情 |