3-(Benzyloxy)-1,2-dimethyl-4(1H)-pyridinone -Drug Synthesis Database

【结构式】

【分子编号】12075

【品名】3-(Benzyloxy)-1,2-dimethyl-4(1H)-pyridinone

【CA登记号】

【分子式】C₁₄H₁₅NO₂

【分子量】229.27864

【元素组成】C 73.34% H 6.59% N 6.11% O 13.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

A new synthesis of L1 has been reported: The reaction of 3-benzyloxy-2-methyl-4H-pyran-4-one (I) with methylamine and NaOH in refluxing ethanol gives 3-benzyloxy-1,2-dimethylpyridin-4(1H)-one (II), which is deprotected by hydrogenolysis with H2 over Pd/C in ethanol.

参考文献中间体

合成目标

【1】 Dobbin, P.S.; Hider, R.C.; Porter, J.B.; Sarpong, P.; Hall, A.D.; Xiao, G.; Taylor, P.D.; Van der Helm, D.; Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential. J Med Chem 1993, 36, 17, 2448.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12074	3-(Benzyloxy)-2-methyl-4H-pyran-4-one；3-(benzyloxy)-2-methylpyran-4-one	61049-69-2	C₁₃H₁₂O₃	详情	详情
(II)	12075	3-(Benzyloxy)-1,2-dimethyl-4(1H)-pyridinone		C₁₄H₁₅NO₂	详情	详情

Extended Information