|
【结 构 式】 
|
【药物名称】Deferiprone, CP20, CGP-37391, CP020, L1, Ferriprox, Deferum, Kelfer 【化学名称】3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 【CA登记号】30652-11-0 【 分 子 式 】C7H9NO2 【 分 子 量 】139.15528 |
【开发单位】BTG (Technology Transfer), Cipla (Originator), Royal Free Hospital (Originator), Chiesi (Not Determined), Apotex (Licensee), Cangene (Licensee) 【药理作用】Antagonists to Metals, Specific Antidotes, TREATMENT OF POISONING, DRUG ABUSE & DEPENDENCY, Metal Chelators |
合成路线1
A new synthesis of L1 has been reported: The reaction of 3-benzyloxy-2-methyl-4H-pyran-4-one (I) with methylamine and NaOH in refluxing ethanol gives 3-benzyloxy-1,2-dimethylpyridin-4(1H)-one (II), which is deprotected by hydrogenolysis with H2 over Pd/C in ethanol.
| 【1】 Dobbin, P.S.; Hider, R.C.; Porter, J.B.; Sarpong, P.; Hall, A.D.; Xiao, G.; Taylor, P.D.; Van der Helm, D.; Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential. J Med Chem 1993, 36, 17, 2448. |
Extended Information