• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】11980

【品名】2-propoxyethyl (E)-3-amino-2-butenoate

【CA登记号】

【 分 子 式 】C9H17NO3

【 分 子 量 】187.23892

【元素组成】C 57.73% H 9.15% N 7.48% O 25.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Cerebrocrast is prepared in Hantzsch-type reaction from 2-(propoxy)ethyl acetoacetate (III), 2-(difluoromethoxy)benzaldehyde and ammonia, or from 2-(propoxy)ethyl beta-aminocrotonate (IV) and 2-(difluoromethoxy)benzaldehyde. The necessary raw material, 2-(propoxy)ethyl acetoacetate (III), is prepared from 2-(propoxy)ethanole (II) by acetoacetylation with diketene (I).

1 Klusa, V.; Cerebrocrast. Drugs Fut 1995, 20, 2, 135.
2 Makarova, N.V.; Biseniex, E.A.; Uldrikis, Y.R.; Dubur, G.Y.; Veveris, M.M.; Kimenis, A.A. (Latvian Institute of Organic Synthesis); Alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid. FR 2587701 .
3 Dubur, G.J.; Veveris, M.M.; Weinheimer, G.; Bisenieks, E.A.; Makarova, N.V.; Kimenis, A.A.; Uldrikis, J.R.; Lukevics, E.J.; Dooley, D.; Osswald, H.; Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,4-dicarboxylic acid. Arzneim-Forsch Drug Res 1989, 39, 10, 1185-9.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11367 4-Methylene-2-oxetanone; Acetyl ketene 674-82-8 C4H4O2 详情 详情
(II) 11978 2-Propoxy-1-ethanol; 2-Propoxyethanol 2807-30-9 C5H12O2 详情 详情
(III) 11979 2-propoxyethyl 3-oxobutanoate C9H16O4 详情 详情
(IV) 11980 2-propoxyethyl (E)-3-amino-2-butenoate C9H17NO3 详情 详情
Extended Information