2-propoxyethyl (E)-3-amino-2-butenoate -Drug Synthesis Database

【结构式】

【分子编号】11980

【品名】2-propoxyethyl (E)-3-amino-2-butenoate

【CA登记号】

【分子式】C₉H₁₇NO₃

【分子量】187.23892

【元素组成】C 57.73% H 9.15% N 7.48% O 25.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Cerebrocrast is prepared in Hantzsch-type reaction from 2-(propoxy)ethyl acetoacetate (III), 2-(difluoromethoxy)benzaldehyde and ammonia, or from 2-(propoxy)ethyl beta-aminocrotonate (IV) and 2-(difluoromethoxy)benzaldehyde. The necessary raw material, 2-(propoxy)ethyl acetoacetate (III), is prepared from 2-(propoxy)ethanole (II) by acetoacetylation with diketene (I).

参考文献中间体

合成目标

【1】 Klusa, V.; Cerebrocrast. Drugs Fut 1995, 20, 2, 135.
【2】 Makarova, N.V.; Biseniex, E.A.; Uldrikis, Y.R.; Dubur, G.Y.; Veveris, M.M.; Kimenis, A.A. (Latvian Institute of Organic Synthesis); Alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid. FR 2587701 .
【3】 Dubur, G.J.; Veveris, M.M.; Weinheimer, G.; Bisenieks, E.A.; Makarova, N.V.; Kimenis, A.A.; Uldrikis, J.R.; Lukevics, E.J.; Dooley, D.; Osswald, H.; Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,4-dicarboxylic acid. Arzneim-Forsch Drug Res 1989, 39, 10, 1185-9.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11367	4-Methylene-2-oxetanone; Acetyl ketene	674-82-8	C₄H₄O₂	详情	详情
(II)	11978	2-Propoxy-1-ethanol; 2-Propoxyethanol	2807-30-9	C₅H₁₂O₂	详情	详情
(III)	11979	2-propoxyethyl 3-oxobutanoate		C₉H₁₆O₄	详情	详情
(IV)	11980	2-propoxyethyl (E)-3-amino-2-butenoate		C₉H₁₇NO₃	详情	详情

Extended Information