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【结 构 式】 
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【分子编号】11979 【品名】2-propoxyethyl 3-oxobutanoate 【CA登记号】 |
【 分 子 式 】C9H16O4 【 分 子 量 】188.22364 【元素组成】C 57.43% H 8.57% O 34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Cerebrocrast is prepared in Hantzsch-type reaction from 2-(propoxy)ethyl acetoacetate (III), 2-(difluoromethoxy)benzaldehyde and ammonia, or from 2-(propoxy)ethyl beta-aminocrotonate (IV) and 2-(difluoromethoxy)benzaldehyde. The necessary raw material, 2-(propoxy)ethyl acetoacetate (III), is prepared from 2-(propoxy)ethanole (II) by acetoacetylation with diketene (I).
| 【1】 Klusa, V.; Cerebrocrast. Drugs Fut 1995, 20, 2, 135. |
| 【2】 Makarova, N.V.; Biseniex, E.A.; Uldrikis, Y.R.; Dubur, G.Y.; Veveris, M.M.; Kimenis, A.A. (Latvian Institute of Organic Synthesis); Alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid. FR 2587701 . |
| 【3】 Dubur, G.J.; Veveris, M.M.; Weinheimer, G.; Bisenieks, E.A.; Makarova, N.V.; Kimenis, A.A.; Uldrikis, J.R.; Lukevics, E.J.; Dooley, D.; Osswald, H.; Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,4-dicarboxylic acid. Arzneim-Forsch Drug Res 1989, 39, 10, 1185-9. |
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