1-(1H-Imidazol-1-yl)-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】11355

【品名】1-(1H-Imidazol-1-yl)-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]-1-ethanone

【CA登记号】

【分子式】C₁₈H₁₇N₃O₂

【分子量】307.352

【元素组成】C 70.34% H 5.58% N 13.67% O 10.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The reaction for preparing the esters is shown schematically by the condensation of 1-methyl-5-(4-methylbenzoyl)pyrrol-2-acetic acid and 7-(2-oxyethyl)theophylline as a general example, giving rise to the formation of the 1-methyl-5-(4-methylbenzoyl)pyrrol-2-acetate of 7-(2-oxyethyl)theophylline.

参考文献中间体

合成目标

【1】 Baglioni, A. (Medosan); Ester derivs. of 7-(omega-oxyalkyl)theophylline and their pharmaceutical activity. EP 0177659; US 4618612 .
【2】 Anzalone, M.; Barone, D.; Pharmacological profile of MED 27, a new platelet antiaggregating agent. Pharmacol Res 1992, 26, Suppl 1, 174.
【3】 Tubaro, E.; MED 27. Drugs Fut 1993, 18, 7, 601.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11352	2-[1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid		C₁₅H₁₅NO₃	详情	详情
(II)	11353	1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole)	530-62-1	C₇H₆N₄O	详情	详情
(III)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情
(IV)	11355	1-(1H-Imidazol-1-yl)-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]-1-ethanone		C₁₈H₁₇N₃O₂	详情	详情
(V)	11356	7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 7-(2-Hydroxy-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione	519-37-9	C₉H₁₂N₄O₃	详情	详情

Extended Information