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【结 构 式】 
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【药物名称】Medosan-27, MED-27 【化学名称】1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetic acid 2-(theophylline-7-yl)ethyl ester 【CA登记号】104333-87-1 【 分 子 式 】C24H25N5O5 【 分 子 量 】463.49735 |
【开发单位】Medosan (Originator) 【药理作用】Antiplatelet Therapy, Asthma Therapy, Bronchodilators, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, RESPIRATORY DRUGS, Methylxanthines, Non-Steroidal Antiinflammatory Drugs, Prostanoid TP (Thromboxane A2) Antagonists, Thromboxane Synthase Inhibitors |
合成路线1
The reaction for preparing the esters is shown schematically by the condensation of 1-methyl-5-(4-methylbenzoyl)pyrrol-2-acetic acid and 7-(2-oxyethyl)theophylline as a general example, giving rise to the formation of the 1-methyl-5-(4-methylbenzoyl)pyrrol-2-acetate of 7-(2-oxyethyl)theophylline.
| 【1】 Baglioni, A. (Medosan); Ester derivs. of 7-(omega-oxyalkyl)theophylline and their pharmaceutical activity. EP 0177659; US 4618612 . |
| 【2】 Anzalone, M.; Barone, D.; Pharmacological profile of MED 27, a new platelet antiaggregating agent. Pharmacol Res 1992, 26, Suppl 1, 174. |
| 【3】 Tubaro, E.; MED 27. Drugs Fut 1993, 18, 7, 601. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11352 | 2-[1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid | C15H15NO3 | 详情 | 详情 | |
| (II) | 11353 | 1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole) | 530-62-1 | C7H6N4O | 详情 | 详情 |
| (III) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (IV) | 11355 | 1-(1H-Imidazol-1-yl)-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]-1-ethanone | C18H17N3O2 | 详情 | 详情 | |
| (V) | 11356 | 7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 7-(2-Hydroxy-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione | 519-37-9 | C9H12N4O3 | 详情 | 详情 |