3-Chloro-6-[4-(3-methylphenyl)piperazino]pyridazine -Drug Synthesis Database

【结构式】

【分子编号】11294

【品名】3-Chloro-6-[4-(3-methylphenyl)piperazino]pyridazine

【CA登记号】

【分子式】C₁₅H₁₇ClN₄

【分子量】288.77964

【元素组成】C 62.39% H 5.93% Cl 12.28% N 19.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

N-Alkylation of 1-(3-methylphenyl)piperazine with 3,6-dichloropyridazine in dimethylformamide as a solvent and in the presence of sodium carbonate afforded 3-chloro-6-[4-(3-methylphenyl-1-piperazinyl]pyridazine. The reactive chlorine atom in this intermediate was replaced by a methoxy group, by refluxing the compound in methanol containing an excess of sodium methoxide. After addition of water to the cooled reaction mixture the product crystallized. Recrystallization from 2-propanol produced pure 3-methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine.

参考文献中间体

合成目标

【1】 Andries, K.; Stokbroekx, R.; R 61837. Drugs Fut 1990, 15, 3, 237.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11292	3,6-Dichloropyridazine	141-30-0	C₄H₂Cl₂N₂	详情	详情
(II)	11293	1-(3-Methylphenyl)piperazine	41186-03-2	C₁₁H₁₆N₂	详情	详情
(III)	11294	3-Chloro-6-[4-(3-methylphenyl)piperazino]pyridazine		C₁₅H₁₇ClN₄	详情	详情

Extended Information